Synovial fluid beta-endorphin level in avascular necrosis, rheumatoid arthritis and osteoarthritis of the femoral head and knee. A controlled pilot study
The goal of this study is to determine and compare the beta- endorphin levels inthe synovial fluid of patients with different joint disorders (avascular necrosis, AVN; steoarthritis, OA; and rheumatoid arthritis, RA of the hip or knee). Eighty-seven patients were involved in our study with an ave...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
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Springer
2011
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| Sorozat: | CLINICAL RHEUMATOLOGY
30 No. 4 |
| doi: | 10.1007/s10067-010-1573-5 |
| mtmt: | 1373174 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/11425 |
| Tartalmi kivonat: | The goal of this study is to determine and compare the beta- endorphin levels inthe synovial fluid of patients with different joint disorders (avascular necrosis, AVN; steoarthritis, OA; and rheumatoid arthritis, RA of the hip or knee). Eighty-seven patients were involved in our study with an average age of 62 years. Thirty-three patients had AVN (18 hips, 15 knees). Twenty-three patients were diagnosed with OA (14 hips, 9 knees), and 31 patients suffered from RA (12 hips, 19 knees). We measured the beta-endorphin levels of the synovial fluids -harvested from surgery-with radioimmunoassay. No significant difference was found in the beta-endorphin levels of the synovial fluid from AVN comparing to OA and RA, however beta-endorphin level was significantly higher in RA group than among patients with OA (p = 0.01). Synovial beta- endorphin level was slightly lower in knee comparing to hip joint p = (0.06). When examining the different joints separately in compliance with diagnoses, we concluded that the synovial beta-endorphin level from AVN was between the values of OA and RA without significant difference, whereas it was significantly higher in the knee of RA, than of OA groups (p = 0.05 knee, p = 0.2 hip). Our results confirmed those experiments which stated that there is a significant increase in synovial beta-endorphin level in patients with inflammatory autoimmune diseases (e.g., RA), comparing to the level measured in degenerative conditions (e.g., OA). |
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| Terjedelem/Fizikai jellemzők: | 537-540 |
| ISSN: | 0770-3198 |