Analysis of the polymorph changes of a drug candidate

The effects of solvents, temperature and humidity on the stability of a former drug candidate obtained from Sanofi (Hungary) were examined by a slurry equilibration method, variable temperature and humidity X-ray powder diffractometry (VT/VH-XRPD) and differential scanning calorimetry (DSC). The VH-...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Langó Péter
Várkonyi E.
Ulrich Joachim
Révész Piroska
Aigner Zoltán
Dokumentumtípus: Cikk
Megjelent: 2015
Sorozat:JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 102
doi:10.1016/j.jpba.2014.09.020

mtmt:2776534
Online Access:http://publicatio.bibl.u-szeged.hu/11099
Leíró adatok
Tartalmi kivonat:The effects of solvents, temperature and humidity on the stability of a former drug candidate obtained from Sanofi (Hungary) were examined by a slurry equilibration method, variable temperature and humidity X-ray powder diffractometry (VT/VH-XRPD) and differential scanning calorimetry (DSC). The VH-XRPD study showed that all 8 polymorphic forms of this material were stable in the interval 20-80 RH%. The VT-XRPD measurements indicated that all the polymorphs except Form II underwent changes in the range 30-200 degrees C. The stable form was Form II, though Form IVb had almost the same stability. The investigation demonstrated that VT-XRPD is a very useful in situ method for relative stability studies.
Terjedelem/Fizikai jellemzők:229-235
ISSN:0731-7085