Analysis of the polymorph changes of a drug candidate
The effects of solvents, temperature and humidity on the stability of a former drug candidate obtained from Sanofi (Hungary) were examined by a slurry equilibration method, variable temperature and humidity X-ray powder diffractometry (VT/VH-XRPD) and differential scanning calorimetry (DSC). The VH-...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2015
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| Sorozat: | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
102 |
| doi: | 10.1016/j.jpba.2014.09.020 |
| mtmt: | 2776534 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/11099 |
| Tartalmi kivonat: | The effects of solvents, temperature and humidity on the stability of a former drug candidate obtained from Sanofi (Hungary) were examined by a slurry equilibration method, variable temperature and humidity X-ray powder diffractometry (VT/VH-XRPD) and differential scanning calorimetry (DSC). The VH-XRPD study showed that all 8 polymorphic forms of this material were stable in the interval 20-80 RH%. The VT-XRPD measurements indicated that all the polymorphs except Form II underwent changes in the range 30-200 degrees C. The stable form was Form II, though Form IVb had almost the same stability. The investigation demonstrated that VT-XRPD is a very useful in situ method for relative stability studies. |
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| Terjedelem/Fizikai jellemzők: | 229-235 |
| ISSN: | 0731-7085 |