Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3

Amnesia is a deficit in memory caused by brain damage, disease, or trauma. Until now, there are no successful medications on the drug market available to treat amnesia. Short analogs and mimetics of human urocortin 3 (Ucn 3) tripeptide were synthesized and tested for their action against amnesia i...

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Bibliographic Details
Main Authors: Telegdy Gyula
Kovács Anita Kármen
Rákosi Kinga
Zarándi Márta
Tóth Gábor
Format: Article
Published: 2016
Series:AMINO ACIDS 48 No. 9
doi:10.1007/s00726-016-2268-2

mtmt:3087496
Online Access:http://publicatio.bibl.u-szeged.hu/10459
Description
Summary:Amnesia is a deficit in memory caused by brain damage, disease, or trauma. Until now, there are no successful medications on the drug market available to treat amnesia. Short analogs and mimetics of human urocortin 3 (Ucn 3) tripeptide were synthesized and tested for their action against amnesia induced by eletroconvulsion in mice. Among the 16 investigated derivs. of Ucn 3 tripeptide, eight compds. displayed antiamnesic effect. Our results proved that the configuration of chiral center of glutamine does not affect the antiamnesic properties. Alkyl amide or isoleucyl amide at the C-terminus may lead to antiamnesic compds. As concerned the N-terminus, acetyl, Boc, and alkyl ureido moieties were found among the active analogs, but the free amino function at the N-terminus usually led to an inactive derivs. These observations may lead to the design and synthesis of small peptidomimetics and amino acid derivs. as antiamnesic drug candidates, although the elucidation of the mechanism of the action requires further investigations. [on SciFinder(R)]
Physical Description:2261-2266
ISSN:0939-4451