Small Peptides Derived from Penetratin as Antibacterial Agents
The synthesis, in vitro evaluation and conformational study of several small-size peptides acting as antibacterial agents are reported. Among the compds. evaluated, the peptides Arg-Gln-Ile-Lys-Ile-Trp-Arg-Arg-Met-Lys-Trp-Lys-Lys-NH2, Arg-Gln-Ile-Lys-Ile-Arg-Arg-Met-Lys-Trp-Arg-NH2, and Arg-Gln-Ile...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | ARCHIV DER PHARMAZIE
349 No. 4 |
| doi: | 10.1002/ardp.201500419 |
| mtmt: | 3054649 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/10457 |
| Tartalmi kivonat: | The synthesis, in vitro evaluation and conformational study of several small-size peptides acting as antibacterial agents are reported. Among the compds. evaluated, the peptides Arg-Gln-Ile-Lys-Ile-Trp-Arg-Arg-Met-Lys-Trp-Lys-Lys-NH2, Arg-Gln-Ile-Lys-Ile-Arg-Arg-Met-Lys-Trp-Arg-NH2, and Arg-Gln-Ile-Trp-Trp-Trp-Trp-Gln-Arg-NH2 exhibited significant antibacterial activity. These were found to be very active antibacterial compds., considering their small mol. size. To better understand the antibacterial activity obtained for these peptides, an exhaustive conformational anal. was performed, using both theor. calcns. and exptl. measurements. Mol. dynamics simulations using two different media (water and trifluoroethanol/water) were employed. The results of these theor. calcns. were corroborated by exptl. CD measurements. A brief discussion on the possible mechanism of action of these peptides at mol. level is also presented. Some of the peptides reported here constitute very interesting structures to be used as starting compds. for the design of new small-size peptides possessing antibacterial activity. [on SciFinder(R)] |
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| Terjedelem/Fizikai jellemzők: | 242-251 |
| ISSN: | 0365-6233 |