Non-genomic actions of steroid hormones in pregnant and non-pregnant uterine tissues in vivo and vitro studies /
It is known that the results of the non-genomic action can be the same as or even different from the effects mediated through the genomic pathway. For example, in the cardiovascular system and diabetes mellitus, the outcome of both signaling pathways is the same 27–30, but in breast cancer cell line...
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| Dokumentumtípus: | Disszertáció |
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2023-01-20
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| doi: | 10.14232/phd.11519 |
| mtmt: | 34117827 |
| Online Access: | http://doktori.ek.szte.hu/11519 |
| Tartalmi kivonat: | It is known that the results of the non-genomic action can be the same as or even different from the effects mediated through the genomic pathway. For example, in the cardiovascular system and diabetes mellitus, the outcome of both signaling pathways is the same 27–30, but in breast cancer cell lines, their actions can be the opposite 26. Since the prompt actions of steroids on uterine contractility are not fully explored yet, we aimed to investigate the fast, non-genomic action of sex steroids (E2, progesterone (P4), T) and corticosteroids (MC fludrocortisone (FLD) and GC (DEX)) on uterine contractions and signaling pathways both late (22-day) pregnant and non-pregnant rats in vitro and in vivo as well. |
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