Glycolipidomics of human cerebellum in development and aging by ion mobility tandem mass spectrometry
In this study ion mobility separation (IMS) mass spectrometry (MS) was for the first time introduced in human cerebellum ganglioside research. The work was focused on a comprehensive mapping and structural characterization of human cerebellar gangliosides and determination of the specific changes in...
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| Dokumentumtípus: | Könyv része |
| Megjelent: |
University of Szeged
Szeged
2023
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
29 |
| Kulcsszavak: | Tömegspektrometria |
| Tárgyszavak: | |
| Online Access: | http://acta.bibl.u-szeged.hu/82376 |
| Tartalmi kivonat: | In this study ion mobility separation (IMS) mass spectrometry (MS) was for the first time introduced in human cerebellum ganglioside research. The work was focused on a comprehensive mapping and structural characterization of human cerebellar gangliosides and determination of the specific changes induced in their expression by brain development and aging. We have carried out a comparative IMS MS mapping of the native ganglioside mixtures extracted from fetal cerebellum in the second trimester of pregnancy vs. near-term fetus vs. aged cerebellum, followed by IMS CID MS/MS fragmentation analysis. |
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| Terjedelem/Fizikai jellemzők: | 95-96 |
| ISBN: | 978-963-306-963-9 |