Investigation of the transformation of 5-fluorouracil cytostatics by UV and VUV photolysis

In this work, UV (254 nm), UV/VUV185 nm, and VUV172 nm photolysis of 5-fluorouracil (5- FLU), a cytostatic drug were investigated. For the water treatments three type of lightsources were applied: a low-pressure mercury vapour lamps emitting only 254 nm UV light, an other low-pressure mercury vapour...

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Bibliographic Details
Main Authors: Dercze Dávid
Farkas Luca
Alapi Tünde
Corporate Author: International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged)
Format: Book part
Published: 2020
Series:Proceedings of the International Symposium on Analytical and Environmental Problems 26
Kulcsszavak:Analitikai kémia
Subjects:
Online Access:http://acta.bibl.u-szeged.hu/74043
Description
Summary:In this work, UV (254 nm), UV/VUV185 nm, and VUV172 nm photolysis of 5-fluorouracil (5- FLU), a cytostatic drug were investigated. For the water treatments three type of lightsources were applied: a low-pressure mercury vapour lamps emitting only 254 nm UV light, an other low-pressure mercury vapour lamps emitting both 254 nm UV and 185 nm VUV light, and a Xe excimer light source emitting 172 nm VUV photons. In parallel, with the transformation of 5-FLU, H2O2 formation was detected and measured. During UV/VUV185 nm photolysis, the formation of H2O2 follows a maximum curve, while in the case of UV photolysis, it shows a saturation curve. Its concentration reached higher value in the case of UV/VUV185 nm than in UV radiation. To enhance the efficiency of the reactors, we used air, O2 and N2 gases and assessed their effect to the photolysis of 5-FLU to see wich parameters are the most suitable for transforming it.
Physical Description:379-383
ISBN:978-963-306-771-0