Anticancer 8-hydroxyquinoline-amino acid hybrids and their half-sandwich Ru and Rh complexes solution chemistry and interaction with biomolecules /

Development of novel chemotherapeutic agents aims to obtain more effective and selective compounds. Platinum(II)-containing chemotherapeutics have been widely used for decades in cancer therapy against solid tumors due to their effectiveness; although, their use is accompanied by drawbacks such the...

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Elmentve itt :
Bibliográfiai részletek
Szerzők: Pivarcsik Tamás
Dömötör Orsolya
Mészáros János P.
May Nóra V.
Csuvik Oszkár
Fülöp Ferenc
Spengler Gabriella
Szatmári István
Enyedy Éva Anna
Testületi szerző: International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged)
Dokumentumtípus: Könyv része
Megjelent: 2020
Sorozat:Proceedings of the International Symposium on Analytical and Environmental Problems 26
Kulcsszavak:Kémia
Tárgyszavak:
Online Access:http://acta.bibl.u-szeged.hu/74017
Leíró adatok
Tartalmi kivonat:Development of novel chemotherapeutic agents aims to obtain more effective and selective compounds. Platinum(II)-containing chemotherapeutics have been widely used for decades in cancer therapy against solid tumors due to their effectiveness; although, their use is accompanied by drawbacks such the serious side-effects and resistance [1]. To overcome these problems, efforts have been made to find better alternatives such as the complexes of other platinum metals. 8-hydroxyquinolines and their metal complexes are widely investigated due to their anticancer properties [2,3]; however, they often have limited water solubility. In this work two novel water-soluble 8-hydroxyquinoline-D-amino acid hybrids, [(R)-1-((5-chloro-8- hydroxyquinolin-7-yl)methyl)pyrrolidine-2-carboxylic acid (8HQCl-D-Pro) and its homologue 8HQCl-D-hPro (Chart 1), and their [Ru(η6 -p-cymene)(H2O)3] 2+ and [Rh(η5 -C5Me5)(H2O)3] 2+ complexes were developed.
Terjedelem/Fizikai jellemzők:289-291
ISBN:978-963-306-771-0