Novel cobalt complexes with glyoximes synthesis, physicochemical analysis and biological study /

Azomethine derivatives have several applications, especially as reagents for the determination of transition metal ions. Furthermore these ligands and their cobalt complexes were also reported to possess biological activities, such as antimicrobial, anti-tubercular, anticonvulsant, anti-inflammatory...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Várhelyi Csaba
Szalay Roland
Pokol György
Goga Firuţa
Huszthy Péter
Madarász János
Simon-Várhelyi Melinda
Tötös Róbert
Avram Alexandra
Testületi szerző: International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged)
Dokumentumtípus: Könyv része
Megjelent: 2020
Sorozat:Proceedings of the International Symposium on Analytical and Environmental Problems 26
Kulcsszavak:Környezetkémia
Tárgyszavak:
Online Access:http://acta.bibl.u-szeged.hu/73953
Leíró adatok
Tartalmi kivonat:Azomethine derivatives have several applications, especially as reagents for the determination of transition metal ions. Furthermore these ligands and their cobalt complexes were also reported to possess biological activities, such as antimicrobial, anti-tubercular, anticonvulsant, anti-inflammatory, anti-proliferative activities as well as antifungal inhibition potential [1]. Another reason for using metal-containing compounds as structural scaffolds is related to the kinetic stability of their coordination spheres in the biological environment. Metallic ions have been shown to play important role in the biological activity of different compounds in such away that, in some cases, activity is enhanced or only takes place in the presence of these ions [2]. In our research new cobalt(III) complexes were synthesized with -glyoximes, azides, amines, thiocyanate and halogens, such as [Co(Me-propyl-GlyoxH)2(N3)(amine)], [Co(Mepentyl-GlyoxH)2(N3)(amine)], [Co(Et-propyl-GlyoxH)2(N3)(amine)], [Co(Et-propylGlyoxH)2(Br)(amine)], [Co(Et-propyl-GlyoxH)2(SCN)(amine)], H[Co(Et-propylGlyoxH)2(SCN)2], [Co(phenyl-Me-GlyoxH)2(amine)2]I, [Co(Et-propyl-GlyoxH)2(amine)2]I, [Co(Et-Bu-GlyoxH)2(amine)2]I, where GlyoxH = mono deprotonated glyoxime, and the used amines: imidazole, 3-hydroxy-aniline, lepidine, 3,5-dimethyl-pyridine, di(n-butyl)-amine, diisopropyl-amine, 2-amino-pyrimidine, diphenyl-amine, 2-picoline, 3-picoline. The Co(II)- acetate salt dissolved in water and mixed with the glyoxime alcoholic solution was oxidized by air bubbling, then the corresponding diamines and the other complexing agents were added. The molecular structure of our products was investigated by IR, UV–VIS spectroscopy, mass spectrometry (MS), thermoanalytical measurements (TG-DTG-DTA), and powder XRD. The biological activity, like antimicrobial effect, was studied for a few bacteria.
Terjedelem/Fizikai jellemzők:62-66
ISBN:978-963-306-771-0