Enzymatic N-alkoxycarbonylation of 1-substituted 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines substrate specificity /
In view of substrate specificity, CAL-B-catalysed asymmetric N-alkoxycarbonylations of 1- substituted 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines (Et, Pr, iPr, t-Bu, Ph) have been studied. High enantioselectivities (>200) were observed, when the reactions were performed from the substrates‘ HCl...
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| Dokumentumtípus: | Könyv része |
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2019
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
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| Kulcsszavak: | Gyógyszerkémia |
| Online Access: | http://acta.bibl.u-szeged.hu/64864 |
| Tartalmi kivonat: | In view of substrate specificity, CAL-B-catalysed asymmetric N-alkoxycarbonylations of 1- substituted 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines (Et, Pr, iPr, t-Bu, Ph) have been studied. High enantioselectivities (>200) were observed, when the reactions were performed from the substrates‘ HCl salts in triethylamine in the presence of allyl phenyl carbonate at 60°C using incubator shaker. The reaction time increased with increasing substituent size in position 1; however, the isopropyl- and t-buthyl-substituted compounds proved to be too bulky for the optimum activity of CAL-B. |
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| Terjedelem/Fizikai jellemzők: | 312-314 |
| ISBN: | 978-963-306-702-4 |