Synthesis of novel Pt complexes with α-glyoximes, schiff bases and their physical-chemical and biological study
Platinum-complexes permanently play an important role in the medical treatment of tumor cells. Since Pt has a soft-type Lewis acidic character, it forms the most stable complexes with S, P, N and I donor atoms, resulting planar (cisplatine) or octahedral (satraplatine) arrangement of ligands. In our...
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| Dokumentumtípus: | Könyv része |
| Megjelent: |
2018
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
24 |
| Kulcsszavak: | Szerves kémia, Biotechnológia |
| Online Access: | http://acta.bibl.u-szeged.hu/56271 |
| Tartalmi kivonat: | Platinum-complexes permanently play an important role in the medical treatment of tumor cells. Since Pt has a soft-type Lewis acidic character, it forms the most stable complexes with S, P, N and I donor atoms, resulting planar (cisplatine) or octahedral (satraplatine) arrangement of ligands. In our research, new platinum complexes were synthesized with α-glyoximes, such as [Pt(diethyl-glyoxH)2(amine)2], where glyoxH = mono deprotonated glyoxime, amine = imidazole, 2-amino-pyrimidine or 3-hydroxy-aniline, and with Schiff bases, such as [Pt(3-heptanone)2(en)], [Pt(3-heptanone)2(1,2-pn)], [Pt(3-heptanone)2(1,3-pn)] (en = ethylenediamine, pn = propylenediamine). The Schiff bases were obtained with the condensation reaction between 3-heptanone and the corresponding diamines. The molecular structure of our products has been investigated by IR, UV–VIS and NMR spectroscopy, MS, thermoanalytical measurements (TG-DTG-DTA), and powder XRD. The biological activity study of compounds revealed their possible application in medical point of view since some of them proved to act as antibacterial agents and potential anticancer drugs. On the other hand, some members of the family of complexes can play catalytic role in organic chemistry transformations. |
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| Terjedelem/Fizikai jellemzők: | 26-30 |
| ISBN: | 978-963-306-623-2 |