Analysis of new synthetic cannabinoid in human urine by LC-MS/MS

Synthetic cannabinoids (SCs) are a group of novel psychoactive substances, which bind to cannabinoid receptors (CB1 and CB2). One of the largest groups of SCs are smoking mixtures, which are intended as legal replacements of cannabis and distributed on the illicit drug market. In 2016, 11 new SCs we...

Full description

Saved in:
Bibliographic Details
Main Authors: Körmöczi Tímea
Sija Éva
Berkecz Róbert
Corporate Author: International Symposium on Analytical and Environmental Problems (23.) (2017) (Szeged)
Format: Book part
Published: 2017
Series:Proceedings of the International Symposium on Analytical and Environmental Problems 23
Kulcsszavak:Analitikai kémia
Online Access:http://acta.bibl.u-szeged.hu/56249
Description
Summary:Synthetic cannabinoids (SCs) are a group of novel psychoactive substances, which bind to cannabinoid receptors (CB1 and CB2). One of the largest groups of SCs are smoking mixtures, which are intended as legal replacements of cannabis and distributed on the illicit drug market. In 2016, 11 new SCs were reported by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). The most commonly used techniques for quantitation of SCs in urine are high performance liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). In this study we analysed in 2016-2017 released 6 new SCs such as 5F-MN18, AMB-CHMINACA, AMB-FUBINACA, APP-CHMINACA, CUMYL-4CNBINACA and THJ-2201. The LC-MS/MS system was optimised and the mass of identified parent ions, daughter ions and related retention time were determined. Matrix effect, extraction recovery and process efficiency were evaluated by the method proposed by Matuszewski et al.
Physical Description:457-462
ISBN:978-963-306-563-1