Environmentally benign catalysis asymmetric Michael-additions using homogeneous and heterogenized chiral 1,2-diamine derivatives /
We have studied the asymmetric Michael-addition of aldehydes to maleimides using optically pure 1,2-diamine catalysts. Investigations on the effect of the structure of the catalyst, maleimide and aldehyde led to valuable conclusions as concern the steric and electronic requirements for obtaining hig...
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| Dokumentumtípus: | Könyv része |
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2017
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| Sorozat: | Proceedings of the International Symposium on Analytical and Environmental Problems
23 |
| Kulcsszavak: | Fotokatalízis, Katalízis, Szerves kémia |
| Online Access: | http://acta.bibl.u-szeged.hu/56248 |
| Tartalmi kivonat: | We have studied the asymmetric Michael-addition of aldehydes to maleimides using optically pure 1,2-diamine catalysts. Investigations on the effect of the structure of the catalyst, maleimide and aldehyde led to valuable conclusions as concern the steric and electronic requirements for obtaining high activities and stereoselectivities in these asymmetric reactions. Based on these observations a plausible reaction intermediate for explaining the stereoselective addition of the nucleophile to the activated olefin is suggested. Furthermore, the results were used for selecting the chiral catalyst and the appropriate linker for the preparation of heterogenized chiral materials. The activities and enantioselectivities obtained using the catalysts immobilized on a proper support approached those obtained with their soluble counterparts and kept their stereoselectivities upon reuse. |
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| Terjedelem/Fizikai jellemzők: | 453-456 |
| ISBN: | 978-963-306-563-1 |