Effect of histaminase treatment on histamine and anaphylactic shock in guinea pigs

In guinea pigs, the intravenous injection of histaminase 15 minutes before the intraabdominal injection of 4 mgm. of histamine prevented in most instances the symptoms of histamineshock. Of 10 control animals, all showed marked symptoms within 5 to 7 minutes and 7 animals died shortly after. Of the...

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Bibliographic Details
Main Authors: Karády Sándor
Browne J. S. L.
Format: Book part
Published: 1941
Series:Közlemények a szegedi kir. magy. Ferencz József-Tudományegyetem belgyógyászati klinikájáról
Közlemények a szegedi kir. magy. Ferencz József-Tudományegyetem belgyógyászati klinikájáról 1940-1941
Kulcsszavak:Állatkísérletek, Tengeri malac, Allergia - hisztamin, Anafilaxia, Immunológia
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Online Access:http://acta.bibl.u-szeged.hu/54212
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Summary:In guinea pigs, the intravenous injection of histaminase 15 minutes before the intraabdominal injection of 4 mgm. of histamine prevented in most instances the symptoms of histamineshock. Of 10 control animals, all showed marked symptoms within 5 to 7 minutes and 7 animals died shortly after. Of the 20 animals pretreated with histaminase, 6 showed slight symptoms after 15 minutes, which disappeared in a few minutes in all but 2 animais that died 55 minutes after the injection of the histamine. 2. Histaminase given intravenously 15 minutes before the administration of egg-white intruabdominally to previously sensitized guinea pigs prevented an anaphylactic shock completely in 15 out of 20 animals. The other 5 guinea, pigs showed only very slight symptoms beginning 20 minutes after the injection of egg-white and lasting for a few minutes. Of the 10 control animals all showed severe anaphylactic shock developing within 5 to 10 minutes and 4 animals died 10 to 14 minutes after the injection of the egg-white.
Physical Description:1-6