Effects of valproate on the dopaminergic system in mice

Valproate is a widely used antiepileptic drug with a known tremor-inducing effect. In this study, we tested the behavioral changes induced by valproate and its effect on the dopaminergic cells in the substantia nigra of mice. This treatment led to a spontaneous locomotor activity, while the explorat...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Vámos Enikő
Csáti Anett
Vécsei László
Klivényi Péter
Dokumentumtípus: Cikk
Megjelent: Maney 2009
Sorozat:NEUROLOGICAL RESEARCH 31 No. 3
doi:10.1179/174313208X346099

mtmt:1234189
Online Access:http://publicatio.bibl.u-szeged.hu/9960
Leíró adatok
Tartalmi kivonat:Valproate is a widely used antiepileptic drug with a known tremor-inducing effect. In this study, we tested the behavioral changes induced by valproate and its effect on the dopaminergic cells in the substantia nigra of mice. This treatment led to a spontaneous locomotor activity, while the explorative behavior was unaltered. The number of dopaminergic cells in the substantia nigra was reduced after valproate treatment. These data are indicative of dopaminergic toxicity, but further studies are needed to demonstrate the exact mechanism. [Neurol Res 2009; 31: 217-219]
Terjedelem/Fizikai jellemzők:217-219
ISSN:0161-6412