Periosteal microcirculatory reactions in a zoledronate-induced osteonecrosis model of the jaw in rats
OBJECTIVES: Nitrogen-containing bisphosphonates induce osteonecrosis mostly in the jaw and less frequently in other bones. Because of the crucial role of periosteal perfusion in bone repair, we investigated zoledronate-induced microcirculatory reactions in the mandibular periosteum in comparison wit...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2015
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| Sorozat: | CLINICAL ORAL INVESTIGATIONS
19 No. 6 |
| doi: | 10.1007/s00784-014-1347-6 |
| mtmt: | 2770515 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/9458 |
| LEADER | 03065nab a2200349 i 4500 | ||
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| 005 | 20191204141338.0 | ||
| 008 | 160713s2015 hu o 0|| zxx d | ||
| 022 | |a 1432-6981 | ||
| 024 | 7 | |a 10.1007/s00784-014-1347-6 |2 doi | |
| 024 | 7 | |a 2770515 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Janovszky Ágnes | |
| 245 | 1 | 0 | |a Periosteal microcirculatory reactions in a zoledronate-induced osteonecrosis model of the jaw in rats |h [elektronikus dokumentum] / |c Janovszky Ágnes |
| 260 | |c 2015 | ||
| 300 | |a 1279-1288 | ||
| 490 | 0 | |a CLINICAL ORAL INVESTIGATIONS |v 19 No. 6 | |
| 520 | 3 | |a OBJECTIVES: Nitrogen-containing bisphosphonates induce osteonecrosis mostly in the jaw and less frequently in other bones. Because of the crucial role of periosteal perfusion in bone repair, we investigated zoledronate-induced microcirculatory reactions in the mandibular periosteum in comparison with those in the tibia in a clinically relevant model of bisphosphonate-induced medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND METHODS: Sprague-Dawley rats were treated with zoledronate (ZOL; 80 i.v. mug/kg/week over 8 weeks) or saline vehicle. The first two right mandibular molar teeth were extracted after 3 weeks. Various systemic and local (periosteal) microcirculatory inflammatory parameters were examined by intravital videomicroscopy after 9 weeks. RESULTS: Gingival healing disorders ( approximately 100 %) and MRONJ developed in 70 % of ZOL-treated cases but not after saline (shown by micro-CT). ZOL induced significantly higher degrees of periosteal leukocyte rolling and adhesion in the mandibular postcapillary venules (at both extraction and intact sites) than at the tibia. Leukocyte NADPH-oxidase activity was reduced; leukocyte CD11b and plasma TNF-alpha levels were unchanged. CONCLUSION: Chronic ZOL treatment causes a distinct microcirculatory inflammatory reaction in the mandibular periosteum but not in the tibia. The local reaction in the absence of augmented systemic leukocyte inflammatory activity suggests that topically different, endothelium-specific changes may play a critical role in the pathogenesis of MRONJ. CLINICAL RELEVANCE: This model permits for the first time to explore the microvascular processes in the mandibular periosteum after chronic ZOL treatment. This approach may contribute to a better understanding of the pathomechanism and the development of strategies to counteract bisphosphonate-induced side effects. | |
| 700 | 0 | 1 | |a Szabó Andrea |e aut |
| 700 | 0 | 1 | |a Varga Renáta |e aut |
| 700 | 0 | 1 | |a Garab Dénes |e aut |
| 700 | 0 | 1 | |a Boros Mihály |e aut |
| 700 | 0 | 1 | |a Mester Csilla |e aut |
| 700 | 0 | 1 | |a Beretka Nikolett |e aut |
| 700 | 0 | 1 | |a Zombori Tamás |e aut |
| 700 | 0 | 1 | |a Wiesmann Hans-Peter |e aut |
| 700 | 0 | 1 | |a Bernhardt Ricardo |e aut |
| 700 | 0 | 1 | |a Ocsovszki Imre |e aut |
| 700 | 0 | 1 | |a Balázs Péter Attila |e aut |
| 700 | 0 | 1 | |a Piffkó József |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/9458/1/Janovszky_Clin_Oral_Inv_2015_u.pdf |z Dokumentum-elérés |