Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling
CHF upregulates fibroblast KCNJ2 expression and currents, thereby hyperpolarizing RMP, increasing Ca(2+) entry, and enhancing atrial fibroblast proliferation. These effects are likely mediated by microRNA-26a downregulation. Remodeling-induced fibroblast KCNJ2 expression changes may play a role in a...
Elmentve itt :
Szerzők: |
Qi Xiao-Yan Huang Hai Ördög Balázs Luo Xiaobin Naud Patrice Sun Yiguo Wu Chia-Tung Dawson Kristin Tadevosyan Artavazd Chen Yu Harada Masahide Dobrev Dobromir Nattel Stanley |
---|---|
Dokumentumtípus: | Cikk |
Megjelent: |
2015-02-27
|
Sorozat: | Circulation research
116 No. 5 |
doi: | 10.1161/CIRCRESAHA.116.305326 |
mtmt: | 2826704 |
Online Access: | http://publicatio.bibl.u-szeged.hu/9042 |
Hasonló tételek
-
Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation
Szerző: Harada Masahide, et al.
Megjelent: (2012) -
[Ca2+]i-induced augmentation of the inward rectifier potassium current (IK1) in canine and human ventricular myocardium
Szerző: Nagy Norbert, et al.
Megjelent: (2015) -
Low Resting Membrane Potential and Low Inward Rectifier Potassium Currents Are Not Inherent Features of hiPSC-Derived Cardiomyocytes
Szerző: Horváth András, et al.
Megjelent: (2018) -
Inhibition of G Protein-Activated Inwardly Rectifying K+ Channels by Extracts of Polygonum persicaria and Isolation of New Flavonoids from the Chloroform Extract of the Herb
Szerző: Lajter Ildikó, et al.
Megjelent: (2013) -
Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained β-adrenergic activation in guinea pig hearts
Szerző: Aflaki Mona, et al.
Megjelent: (2014)