Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling
CHF upregulates fibroblast KCNJ2 expression and currents, thereby hyperpolarizing RMP, increasing Ca(2+) entry, and enhancing atrial fibroblast proliferation. These effects are likely mediated by microRNA-26a downregulation. Remodeling-induced fibroblast KCNJ2 expression changes may play a role in a...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2015-02-27
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| Sorozat: | Circulation research
116 No. 5 |
| doi: | 10.1161/CIRCRESAHA.116.305326 |
| mtmt: | 2826704 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/9042 |
| LEADER | 01526nab a2200349 i 4500 | ||
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| 005 | 20191016140509.0 | ||
| 008 | 170504s2015 hu o 0|| zxx d | ||
| 022 | |a 1524-4571 | ||
| 024 | 7 | |a 10.1161/CIRCRESAHA.116.305326 |2 doi | |
| 024 | 7 | |a 2826704 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Qi Xiao-Yan | |
| 245 | 1 | 0 | |a Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling |h [elektronikus dokumentum] / |c Qi Xiao-Yan |
| 260 | |c 2015-02-27 | ||
| 300 | |a 836-45 | ||
| 490 | 0 | |a Circulation research |v 116 No. 5 | |
| 520 | 3 | |a CHF upregulates fibroblast KCNJ2 expression and currents, thereby hyperpolarizing RMP, increasing Ca(2+) entry, and enhancing atrial fibroblast proliferation. These effects are likely mediated by microRNA-26a downregulation. Remodeling-induced fibroblast KCNJ2 expression changes may play a role in atrial fibrillation promoting fibroblast remodeling and structural/arrhythmic consequences. | |
| 700 | 0 | 1 | |a Huang Hai |e aut |
| 700 | 0 | 1 | |a Ördög Balázs |e aut |
| 700 | 0 | 1 | |a Luo Xiaobin |e aut |
| 700 | 0 | 1 | |a Naud Patrice |e aut |
| 700 | 0 | 1 | |a Sun Yiguo |e aut |
| 700 | 0 | 1 | |a Wu Chia-Tung |e aut |
| 700 | 0 | 1 | |a Dawson Kristin |e aut |
| 700 | 0 | 1 | |a Tadevosyan Artavazd |e aut |
| 700 | 0 | 1 | |a Chen Yu |e aut |
| 700 | 0 | 1 | |a Harada Masahide |e aut |
| 700 | 0 | 1 | |a Dobrev Dobromir |e aut |
| 700 | 0 | 1 | |a Nattel Stanley |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/9042/1/Circulation%20Research-2015-Qi.pdf |z Dokumentum-elérés |