Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation
TRPC3 channels regulate cardiac fibroblast proliferation and differentiation, likely by controlling the Ca(2+) influx that activates extracellular signal-regulated kinase signaling. AF increases TRPC3 channel expression by causing NFAT-mediated downregulation of microRNA-26 and causes TRPC3-dependen...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2012-10-23
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| Sorozat: | Circulation
126 No. 17 |
| doi: | 10.1161/CIRCULATIONAHA.112.121830 |
| mtmt: | 3079302 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/9037 |
| LEADER | 01977nab a2200421 i 4500 | ||
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| 005 | 20191018152403.0 | ||
| 008 | 170503s2012 hu o 0|| zxx d | ||
| 022 | |a 1524-4539 | ||
| 024 | 7 | |a 10.1161/CIRCULATIONAHA.112.121830 |2 doi | |
| 024 | 7 | |a 3079302 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Harada Masahide | |
| 245 | 1 | 0 | |a Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation |h [elektronikus dokumentum] / |c Harada Masahide |
| 260 | |c 2012-10-23 | ||
| 300 | |a 2051-2064 | ||
| 490 | 0 | |a Circulation |v 126 No. 17 | |
| 520 | 3 | |a TRPC3 channels regulate cardiac fibroblast proliferation and differentiation, likely by controlling the Ca(2+) influx that activates extracellular signal-regulated kinase signaling. AF increases TRPC3 channel expression by causing NFAT-mediated downregulation of microRNA-26 and causes TRPC3-dependent enhancement of fibroblast proliferation and differentiation. In vivo, TRPC3 blockade prevents AF substrate development in a dog model of electrically maintained AF. TRPC3 likely plays an important role in AF by promoting fibroblast pathophysiology and is a novel potential therapeutic target. | |
| 700 | 0 | 1 | |a Luo Xiaobin |e aut |
| 700 | 0 | 1 | |a Qi Xiao Yan |e aut |
| 700 | 0 | 1 | |a Tadevosyan Artavazd |e aut |
| 700 | 0 | 1 | |a Maguy Ange |e aut |
| 700 | 0 | 1 | |a Ördög Balázs |e aut |
| 700 | 0 | 1 | |a Ledoux Jonathan |e aut |
| 700 | 0 | 1 | |a Kato Takeshi |e aut |
| 700 | 0 | 1 | |a Naud Patrice |e aut |
| 700 | 0 | 1 | |a Voigt Niels |e aut |
| 700 | 0 | 1 | |a Shi Yanfen |e aut |
| 700 | 0 | 1 | |a Kamiya Kaichiro |e aut |
| 700 | 0 | 1 | |a Murohara Toyoaki |e aut |
| 700 | 0 | 1 | |a Kodama Itsuo |e aut |
| 700 | 0 | 1 | |a Tardif Jean-Claude |e aut |
| 700 | 0 | 1 | |a Schotten Ulrich |e aut |
| 700 | 0 | 2 | |a Van Wagoner David R. |e aut |
| 700 | 0 | 2 | |a Dobrev Dobromir |e aut |
| 700 | 0 | 2 | |a Nattel Stanley |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/9037/1/Circulation-2012-Harada-2051-64.pdf |z Dokumentum-elérés |