Role of Rho/ROCK signaling in the interaction of melanoma cells with the blood-brain barrier
We have investigated the role of the Rho/ROCK signaling pathway in the interaction of metastatic melanoma cells with the brain endothelium. ROCK inhibition induced a shift of melanoma cells to the mesenchymal phenotype, increased the number of melanoma cells attached to the brain endothelium, and st...
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| Dokumentumtípus: | Cikk |
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Wiley-Blackwell Publishing Ltd.
2014
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| Sorozat: | PIGMENT CELL & MELANOMA RESEARCH
27 No. 1 |
| doi: | 10.1111/pcmr.12169 |
| mtmt: | 2521415 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/8796 |
| LEADER | 02222nab a2200373 i 4500 | ||
|---|---|---|---|
| 001 | publ8796 | ||
| 005 | 20190606131429.0 | ||
| 008 | 170207s2014 hu o 0|| angol d | ||
| 022 | |a 1755-1471 | ||
| 024 | 7 | |a 10.1111/pcmr.12169 |2 doi | |
| 024 | 7 | |a 2521415 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a angol | ||
| 100 | 1 | |a Wilhelm Imola Mária | |
| 245 | 1 | 0 | |a Role of Rho/ROCK signaling in the interaction of melanoma cells with the blood-brain barrier |h [elektronikus dokumentum] / |c Wilhelm Imola Mária |
| 260 | |a Wiley-Blackwell Publishing Ltd. |c 2014 | ||
| 300 | |a 113-123 | ||
| 490 | 0 | |a PIGMENT CELL & MELANOMA RESEARCH |v 27 No. 1 | |
| 520 | 3 | |a We have investigated the role of the Rho/ROCK signaling pathway in the interaction of metastatic melanoma cells with the brain endothelium. ROCK inhibition induced a shift of melanoma cells to the mesenchymal phenotype, increased the number of melanoma cells attached to the brain endothelium, and strengthened the adhesion force between melanoma and endothelial cells. Inhibition of ROCK raised the number of melanoma cells migrating through the brain endothelial monolayer and promoted the formation of parenchymal brain metastases in vivo. We have shown that inhibition of the Rho/ROCK pathway in melanoma, but not in brain endothelial cells, is responsible for this phenomenon. Our results indicate that the mesenchymal type of tumor cell movement is primordial in the transmigration of melanoma cells through the blood-brain barrier. | |
| 700 | 0 | 1 | |a Fazakas Csilla |e aut |
| 700 | 0 | 1 | |a Molnár Judit |e aut |
| 700 | 0 | 1 | |a Haskó János |e aut |
| 700 | 0 | 1 | |a Végh Attila Gergely |e aut |
| 700 | 0 | 1 | |a Cervenak László |e aut |
| 700 | 0 | 1 | |a Nagyőszi Péter |e aut |
| 700 | 0 | 2 | |a Nyúl-Tóth Ádám |e aut |
| 700 | 0 | 2 | |a Farkas Elek Attila |e aut |
| 700 | 0 | 2 | |a Bauer Hannelore |e aut |
| 700 | 0 | 2 | |a Guillemin Gilles J. |e aut |
| 700 | 0 | 2 | |a Bauer Hans-Christian |e aut |
| 700 | 0 | 2 | |a Váró György |e aut |
| 700 | 0 | 2 | |a Krizbai István Adorján |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/8796/1/pcmr_12169_PROOF_corr_u.pdf |z Dokumentum-elérés |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/8796/2/2014_Wilhelm_Fazakas_PCMR_ROCK_u.pdf |z Dokumentum-elérés |