Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells
Betulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. To overcome this inconvenience, a highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-gamma-cyclodextrin). The complex was physico-chemica...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
MDPI AG
2014
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
15 No. 5 |
| doi: | 10.3390/ijms15058235 |
| mtmt: | 2589102 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/8783 |
| LEADER | 02240nab a2200349 i 4500 | ||
|---|---|---|---|
| 001 | publ8783 | ||
| 005 | 20190606125613.0 | ||
| 008 | 170206s2014 hu o 0|| angol d | ||
| 022 | |a 1661-6596 | ||
| 024 | 7 | |a 10.3390/ijms15058235 |2 doi | |
| 024 | 7 | |a 2589102 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a angol | ||
| 100 | 1 | |a Soica Codruta | |
| 245 | 1 | 0 | |a Betulinic Acid in Complex with a Gamma-Cyclodextrin Derivative Decreases Proliferation and in Vivo Tumor Development of Non-Metastatic and Metastatic B164A5 Cells |h [elektronikus dokumentum] / |c Soica Codruta |
| 260 | |a MDPI AG |c 2014 | ||
| 300 | |a 8235-8255 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 15 No. 5 | |
| 520 | 3 | |a Betulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. To overcome this inconvenience, a highly water-soluble cyclodextrin was used (octakis-[6-deoxy-6-(2-sulfanyl ethanesulfonic acid)]-gamma-cyclodextrin). The complex was physico-chemically analyzed using differential scanning calorimetry (DSC), X-ray and scanning electron microscopy (SEM) methods and then in vitro tested for its antiproliferative activity by the MTT assay and by cell cycle analysis. Finally, the complex was tested in vivo using an animal model of murine melanoma developed in C57BL/6J mice, where it caused a reduction in tumor volume and weight. The study revealed the beneficial influence of betulinic acid inclusion into the cyclodextrin in terms of antiproliferative activity and in vivo tumor development. | |
| 700 | 0 | 1 | |a Danciu Corina |e aut |
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| 700 | 0 | 2 | |a Ambrus Rita |e aut |
| 700 | 0 | 2 | |a Zupkó István |e aut |
| 700 | 0 | 2 | |a Bojin Florina |e aut |
| 700 | 0 | 2 | |a Coricovac Dorina |e aut |
| 700 | 0 | 2 | |a Ciurlea Sorina |e aut |
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| 700 | 0 | 2 | |a Dehelean Cristina Adriana |e aut |
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| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/8783/1/Betulinic_Acid_in_Complex_with_a_Gamma_Cyclodextrin_Derivative_Decreases_Proliferation_and_in_Vivo_Tumor_Development_of_Non_Metastatic_and_Metastatic_B164A5_Cells_u.pdf |z Dokumentum-elérés |