Faecal matrix metalloprotease-9 is a more sensitive marker for diagnosing pouchitis than faecal calprotectin results from a pilot study. /
Background: Potential non-invasive markers of pouchitis would have a great deal of significance within clinical practice. Aim: This study is aimed at assessing the diagnostic accuracy of fecal calprotectin and matrix metalloprotease-9 as potential markers in patients both with and without pouchitis....
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2015
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| Sorozat: | EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
9 No. 3 |
| doi: | 10.1586/17474124.2015.965144 |
| mtmt: | 2822839 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/8372 |
| LEADER | 02284nab a2200313 i 4500 | ||
|---|---|---|---|
| 001 | publ8372 | ||
| 005 | 20190415120249.0 | ||
| 008 | 170105s2015 hu o 0|| angol d | ||
| 022 | |a 1747-4124 | ||
| 024 | 7 | |a 10.1586/17474124.2015.965144 |2 doi | |
| 024 | 7 | |a 2822839 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a angol | ||
| 100 | 1 | |a Farkas Klaudia | |
| 245 | 1 | 0 | |a Faecal matrix metalloprotease-9 is a more sensitive marker for diagnosing pouchitis than faecal calprotectin |h [elektronikus dokumentum] : |b results from a pilot study. / |c Farkas Klaudia |
| 260 | |c 2015 | ||
| 300 | |a 387-392 | ||
| 490 | 0 | |a EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY |v 9 No. 3 | |
| 520 | 3 | |a Background: Potential non-invasive markers of pouchitis would have a great deal of significance within clinical practice. Aim: This study is aimed at assessing the diagnostic accuracy of fecal calprotectin and matrix metalloprotease-9 as potential markers in patients both with and without pouchitis. Patients and methods: Stool and blood samples were collected from 33 ileal pouch-anal anastomosis patients before a follow-up pouchoscopy. Biopsy samples were taken for histological purposes. The presence of cuffitis and stenosis was evaluated with an endoscopy. Calprotectin and matrix metalloprotease-9 were quantified with an enzyme-linked immunosorbent assay. Results: Pouchitis was detected in 30.3% of the patients. The levels of fecal calprotectin and matrix metalloprotease-9 increased significantly in patients with pouchitis. The sensitivity and specificity of matrix metalloprotease-9 was higher than that of fecal calprotectin. Only matrix metalloprotease-9 correlated significantly with the severity of pouchitis. Discussion: Fecal matrix metalloprotease-9 has a high specificity in the diagnosis of pouchitis. | |
| 700 | 0 | 1 | |a Bálint Anita |e aut |
| 700 | 0 | 1 | |a Bor Renáta |e aut |
| 700 | 0 | 1 | |a Földesi Imre |e aut |
| 700 | 0 | 1 | |a Szűcs Mónika |e aut |
| 700 | 0 | 1 | |a Nagy Ferenc |e aut |
| 700 | 0 | 1 | |a Szepes Zoltán |e aut |
| 700 | 0 | 1 | |a Annaházi Anita |e aut |
| 700 | 0 | 1 | |a Róka Richárd László |e aut |
| 700 | 0 | 1 | |a Molnár Tamás |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/8372/1/Farkas_2015_Expert_Review_of_Gastroenterology_And_Hepatology_publisher_u.pdf |z Dokumentum-elérés |