Application of Cinchona alkaloid-based zwitterionic chiral stationary phases in supercritical fluid chromatography for the enantioseparation of N-alpha-protected proteinogenic amino acids
Stereoselective supercritical fluid chromatographic separations of the enantiomers of a large set of 1 4Fmoc proteinogenic amino acids were carried out on the recently developed Cinchona alkaloid-based zwitterionic chiral stationary phases Chiralpak ZWIX(+)(TM) and ZWIX(-)(TM) with protic solvents a...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2015
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| Sorozat: | JOURNAL OF CHROMATOGRAPHY A
1415 |
| doi: | 10.1016/j.chroma.2015.08.058 |
| mtmt: | 2958870 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/8111 |
| LEADER | 02304nab a2200265 i 4500 | ||
|---|---|---|---|
| 001 | publ8111 | ||
| 005 | 20190404113625.0 | ||
| 008 | 161219s2015 hu o 0|| angol d | ||
| 022 | |a 0021-9673 | ||
| 024 | 7 | |a 10.1016/j.chroma.2015.08.058 |2 doi | |
| 024 | 7 | |a 2958870 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a angol | ||
| 100 | 1 | |a Lajkó Gyula | |
| 245 | 1 | 0 | |a Application of Cinchona alkaloid-based zwitterionic chiral stationary phases in supercritical fluid chromatography for the enantioseparation of N-alpha-protected proteinogenic amino acids |h [elektronikus dokumentum] / |c Lajkó Gyula |
| 260 | |c 2015 | ||
| 300 | |a 134-145 | ||
| 490 | 0 | |a JOURNAL OF CHROMATOGRAPHY A |v 1415 | |
| 520 | 3 | |a Stereoselective supercritical fluid chromatographic separations of the enantiomers of a large set of 1 4Fmoc proteinogenic amino acids were carried out on the recently developed Cinchona alkaloid-based zwitterionic chiral stationary phases Chiralpak ZWIX(+)(TM) and ZWIX(-)(TM) with protic solvents as cosolvents. The effects of the mobile phase composition, the natures and concentrations of the acid or base additives, the co- and counter-ions and temperature on the separations were investigated. The retention time in most cases slightly increased, while the separation factor decreased with increasing temperature. The changes in standard enthalpy, Delta(Delta H degrees), entropy, Delta(Delta S degrees), and free energy, Delta(Delta G degrees), were calculated from the linear van't Hoff plots derived from the Ina vs 1/T curves in the studied temperature range (20-60 degrees C). The values of the thermodynamic parameters depended on the natures of the selectors and the structures of the analytes. On both ZWIX(+)(TM) and ZWIX(-)(TM) columns, enthalpically-driven separations were observed. The elution sequence was determined in all cases and was observed to be opposite on ZWIX(+)(TM) and ZWIX(-)(TM) which acted for the presented applications as chiral anion exchanger. (C) 2015 Elsevier B.V. All rights reserved. | |
| 700 | 0 | 1 | |a Ilisz István |e aut |
| 700 | 0 | 1 | |a Tóth Gábor |e aut |
| 700 | 0 | 1 | |a Fülöp Ferenc |e aut |
| 700 | 0 | 1 | |a Wolfgang Lindner |e aut |
| 700 | 0 | 1 | |a Péter Antal |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/8111/1/LAJKO_SFC_JCA_1_u.pdf |z Dokumentum-elérés |