Association of FLAIR Positivity and Worse Outcomes After Intravenous Thrombolysis in Known-Onset Strokes A Systematic Review and Meta-Analysis /
Background/Objectives: MRI FLAIR signal serves as a time surrogate in unknown onset strokes; however, its prognostic value in early known-onset strokes treated with intravenous thrombolysis (IVT) remains unclear. We aim to evaluate whether FLAIR positivity predicts hemorrhagic transformation and les...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2025
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| Sorozat: | JOURNAL OF CLINICAL MEDICINE
14 No. 22 |
| Tárgyszavak: | |
| doi: | 10.3390/jcm14228031 |
| mtmt: | 36434001 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/39552 |
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| 008 | 260305s2025 hu o 000 eng d | ||
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| 024 | 7 | |a 10.3390/jcm14228031 |2 doi | |
| 024 | 7 | |a 36434001 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Zhubi Esra | |
| 245 | 1 | 0 | |a Association of FLAIR Positivity and Worse Outcomes After Intravenous Thrombolysis in Known-Onset Strokes |h [elektronikus dokumentum] : |b A Systematic Review and Meta-Analysis / |c Zhubi Esra |
| 260 | |c 2025 | ||
| 300 | |a 15 | ||
| 490 | 0 | |a JOURNAL OF CLINICAL MEDICINE |v 14 No. 22 | |
| 520 | 3 | |a Background/Objectives: MRI FLAIR signal serves as a time surrogate in unknown onset strokes; however, its prognostic value in early known-onset strokes treated with intravenous thrombolysis (IVT) remains unclear. We aim to evaluate whether FLAIR positivity predicts hemorrhagic transformation and less favorable functional outcome following IVT within 4.5 h of symptom onset. Methods: A systematic search of Embase, PubMed, and Cochrane Library was conducted. We included studies reporting 90-day functional outcome and hemorrhagic transformation after intravenous thrombolysis within 4.5 h of symptom onset in relation to the FLAIR signal on pre-treatment MRI. Two reviewers independently extracted data and assessed bias using QUIPS. A random-effects model was used for meta-analysis. The study protocol was registered in PROSPERO (CRD42023486781). Results: Six studies comprising 951 patients were included in the final analysis. Patients with FLAIR-positive lesions (25.86%) had non-significantly higher odds of hemorrhagic transformation (OR, 3.47; 95% CI, 0.51-23.57; p = 0.131) and significantly higher odds of unfavorable 90-day outcome (OR, 2.14; 95% CI, 1.01-4.55; p = 0.049). The pooled sensitivity and specificity of FLAIR status for predicting hemorrhagic transformation were 41.2% and 82.1%. The pooled sensitivity and specificity of FLAIR status for predicting less favorable outcome were 40.9% and 78.1%, respectively. Conclusions: FLAIR positivity is significantly associated with less favorable 90-day functional outcome and a trend toward a higher rate of hemorrhagic transformation following IVT within 4.5 h of symptom onset. It may aid risk stratification but should not preclude treatment in eligible patients. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Bissenov Azamat |e aut |
| 700 | 0 | 1 | |a Lengyel Anna Sára |e aut |
| 700 | 0 | 1 | |a Réka Tóth |e aut |
| 700 | 0 | 1 | |a Horváth András Attila |e aut |
| 700 | 0 | 1 | |a Kéri Szabolcs |e aut |
| 700 | 0 | 1 | |a Engh Marie Anne |e aut |
| 700 | 0 | 1 | |a Hegyi Péter |e aut |
| 700 | 0 | 1 | |a Gunda Bence |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/39552/1/36434001_jcm-14-08031.pdf |z Dokumentum-elérés |