Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood–brain barrier model

Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood–brain barrier model

Targeting the blood–brain barrier (BBB) is a key step for effective brain delivery of nanocarriers. We have previously discovered that combinations of BBB nutrient transporter ligands alanine and glutathione (A-GSH), increase the permeability of vesicular and polypeptide nanocarriers containing mode...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Mészáros Mária
Phan Thi Ha My
Vigh Judit Piroska
Porkoláb Gergő
Kocsis Anna
Szecskó Anikó
Páli Emese Kincső
Cser Nárcisz Mónika
Polgár Tamás Ferenc
Kecskeméti Gábor
Walter Fruzsina
Schwamborn Jens C.
Janáky Tamás
Jan Jeng-Shiung
Veszelka Szilvia
Deli Mária Anna
Dokumentumtípus: Cikk
Megjelent: 2025
Sorozat:FLUIDS AND BARRIERS OF THE CNS 22 No. 1
Tárgyszavak:
Általános orvostudomány
doi:10.1186/s12987-025-00623-2

mtmt:35772795
Online Access:http://publicatio.bibl.u-szeged.hu/38888
Leíró adatok
Tartalmi kivonat:Targeting the blood–brain barrier (BBB) is a key step for effective brain delivery of nanocarriers. We have previously discovered that combinations of BBB nutrient transporter ligands alanine and glutathione (A-GSH), increase the permeability of vesicular and polypeptide nanocarriers containing model cargo across the BBB. Our aim was to investigate dopamine- and ibuprofen-coupled 3-armed poly(<jats:sc>l</jats:sc>-glutamic acid) nanocarriers targeted by A-GSH for transfer across a novel human co-culture model with induced BBB properties. In addition, the protective effect of ibuprofen containing nanoparticles on cytokine-induced barrier damage was also measured.
Terjedelem/Fizikai jellemzők:23
ISSN:2045-8118

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