Health Status Outcomes With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in ISCHEMIA
In ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches), an invasive strategy demonstrated better health status outcomes than a conservative strategy in patients with chronic coronary disease (CCD). Some previous studies have shown greater health st...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2025
|
| Sorozat: | CIRCULATION
152 No. 12 |
| Tárgyszavak: | |
| doi: | 10.1161/CIRCULATIONAHA.125.073591 |
| mtmt: | 36855092 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/38739 |
| LEADER | 03443nab a2200409 i 4500 | ||
|---|---|---|---|
| 001 | publ38739 | ||
| 005 | 20260303135037.0 | ||
| 008 | 260119s2025 hu o 000 eng d | ||
| 022 | |a 0009-7322 | ||
| 024 | 7 | |a 10.1161/CIRCULATIONAHA.125.073591 |2 doi | |
| 024 | 7 | |a 36855092 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Huded Chetan P | |
| 245 | 1 | 0 | |a Health Status Outcomes With Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting in ISCHEMIA |h [elektronikus dokumentum] / |c Huded Chetan P |
| 260 | |c 2025 | ||
| 300 | |a 846-858 | ||
| 490 | 0 | |a CIRCULATION |v 152 No. 12 | |
| 520 | 3 | |a In ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches), an invasive strategy demonstrated better health status outcomes than a conservative strategy in patients with chronic coronary disease (CCD). Some previous studies have shown greater health status benefits with coronary artery bypass grafting (CABG) than percutaneous coronary intervention (PCI). Whether the health status benefits of invasive management in ISCHEMIA were driven primarily by participants treated with CABG is unknown.The aim of this analysis was to describe the health status outcomes of participants treated with a conservative strategy (n=2232) compared with invasively managed participants treated with PCI (n=1198) or CABG (n=340) in ISCHEMIA. The Seattle Angina Questionnaire-7 summary score (SAQ-SS) and angina frequency score (SAQ-AF) were the primary outcomes, with higher scores indicating better health status. Proportional odds models comparing 1- and 3-year outcomes were fit, adjusting for demographic, clinical, and angiographic characteristics.SAQ-SS in the conservative, PCI, and CABG groups increased by 9.9±18.1, 15.7±19.3, and 16.1±19.1 points at 1 year and 11.5±20.2, 16.5±21.8, and 15.0±19.4 points at 3 years, respectively. Freedom from angina in the conservative, PCI, and CABG groups was noted in 61.4%, 73.3%, and 82.4% at 1 year and 70.4%, 76.1%, 81.4% at 3 years, respectively. In risk-adjusted analyses, PCI and CABG were each associated with a higher SAQ-SS and SAQ-AF at 1 and 3 years compared with conservative management. SAQ-AF was higher with CABG than PCI at 1 year (odds ratio, 1.54 [95% CI, 1.03, 2.31]), but no differences between CABG and PCI were observed in SAQ-SS (odds ratio, 1.11 [95% CI, 0.78, 1.57]) or SAQ-AF (odds ratio, 0.94 [95% CI, 0.58, 1.54]) at 3 years.In ISCHEMIA, both PCI and CABG were associated with better 3-year health status than conservative management. Better angina relief with CABG than PCI was seen at 1, but not 3, years.URL: https://www.clinicaltrials.gov; Unique identifier: NCT01471522. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Spertus John A |e aut |
| 700 | 0 | 1 | |a Jones Philip G |e aut |
| 700 | 0 | 1 | |a O'Brien Sean M |e aut |
| 700 | 0 | 1 | |a Mark Daniel B |e aut |
| 700 | 0 | 1 | |a Bangalore Sripal |e aut |
| 700 | 0 | 1 | |a Stone Gregg W |e aut |
| 700 | 0 | 1 | |a Williams David O |e aut |
| 700 | 0 | 1 | |a White Harvey D |e aut |
| 700 | 0 | 1 | |a Boden William E |e aut |
| 700 | 0 | 1 | |a Reynolds Harmony R |e aut |
| 700 | 0 | 1 | |a Hochman Judith S |e aut |
| 700 | 0 | 1 | |a Maron David J |e aut |
| 700 | 0 | 2 | |a Kollaborációs szervezet ISCHEMIA Research Group |e aut |
| 700 | 0 | 2 | |a Varga Albert |e aut |
| 700 | 0 | 2 | |a Ágoston Gergely |e aut |
| 700 | 0 | 2 | |a et al. |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/38739/1/Huded.pdf |z Dokumentum-elérés |