02755nab a2200325 i 4500 publ36166 20250228143116.0 250228s2025 hu o 000 eng d 1661-6596 10.3390/ijms26052062 doi 35793186 mtmt SZTE Publicatio Repozitórium hun eng Bordács Barbara Anikó Comprehensive Assessment of Neuropathy and Metabolic Parameters in Type 1 Diabetic Patients with or Without Using Continuous Glucose Sensors [elektronikus dokumentum] / Bordács Barbara Anikó 2025 11 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 26 No. 5 The present study was conducted in type 1 diabetic (T1DM) patients to evaluate the metabolic and glycemic control as well as the manifestations of neuropathy. The impact of continuous glucose monitoring (CGM) on the measured parameters was also analyzed. A total of 61 T1DM patients (age: 42.5 ± 1.8 years, DM duration: 22.8 ± 1.6 years, mean ± SE) participated in the study. In total, 24 patients had CGM sensors and 37 did not. Cardiovascular autonomic neuropathy was assessed using cardiovascular reflex tests. Peripheral sensory function was evaluated by a Neurometer and calibrated tuning fork on the upper and lower limbs. Metabolic status was characterized by the determination of triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, and glycated haemoglobin (HBA1c). A positive correlation was found between HbA1c and triglyceride levels (r = 0.28, p < 0.05). CGM users and non-users differed in triglyceride (0.9 ± 0.1 vs. 1.24 ± 0.12 mmol/L, p < 0.05), HDL cholesterol (1.7 ± 0.1 vs. 1.4 ± 0.1 p < 0.05 mmol/L), and HbA1C (7.5 ± 0.2 vs. 8.3 ± 0.3%, p < 0.05) levels as well. Significant differences were found for the Valsalva ratio, Neurometer, and calibrated tuning fork results between CGM users and non-users. This study found a significant correlation between HbA1c and triglyceride levels in T1DM. CGM use resulted in improved metabolic parameters and less autonomic and sensory nerve damage. As a novel finding, CGM is presumed to prevent both micro-, and macrovascular complications and, by this way, potentially reducing mortality rates. Klinikai orvostan Várkonyi Ákos aut Valkusz Zsuzsanna aut Nyiraty Szabolcs aut Pósa Anikó aut Menyhárt Adrienn aut Lengyel Csaba Attila aut Kempler Péter aut Kupai Krisztina aut Várkonyi Tamás aut http://publicatio.bibl.u-szeged.hu/36166/1/Bordacs.pdf Dokumentum-elérés