How the Soluble Human Leukocyte Antigen-G levels in Amniotic Fluid and Maternal Serum Correlate with the Feto-Placental Growth in Uncomplicated Pregnancies
Introduction: Trophoblast-derived angiogenic factors are considered to play an important role in the pathophysiology of various complications of pregnancy. Human Leukocyte Antigen-G (HLA-G) belongs to the non-classical human major histocompatibility complex (MHC-I) molecule and has membrane-bound an...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2024
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| Sorozat: | BIOENGINEERING
11 No. 5 |
| Tárgyszavak: | |
| doi: | 10.3390/bioengineering11050509 |
| mtmt: | 34890581 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/35397 |
| LEADER | 02948nab a2200301 i 4500 | ||
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| 024 | 7 | |a 10.3390/bioengineering11050509 |2 doi | |
| 024 | 7 | |a 34890581 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Vincze Márió Attila | |
| 245 | 1 | 0 | |a How the Soluble Human Leukocyte Antigen-G levels in Amniotic Fluid and Maternal Serum Correlate with the Feto-Placental Growth in Uncomplicated Pregnancies |h [elektronikus dokumentum] / |c Vincze Márió Attila |
| 260 | |c 2024 | ||
| 300 | |a 11 | ||
| 490 | 0 | |a BIOENGINEERING |v 11 No. 5 | |
| 520 | 3 | |a Introduction: Trophoblast-derived angiogenic factors are considered to play an important role in the pathophysiology of various complications of pregnancy. Human Leukocyte Antigen-G (HLA-G) belongs to the non-classical human major histocompatibility complex (MHC-I) molecule and has membrane-bound and soluble forms. HLA-G is primarily expressed by extravillous cytotrophoblasts located in the placenta between the maternal and fetal compartments and plays a pivotal role in providing immune tolerance. The aim of this study was to establish a relationship between concentrations of soluble HLA-G (sHLA-G) in maternal serum and amniotic fluid at 16–22 weeks of gestation and the sonographic measurements of fetal and placental growth. Materials and methods: sHLA-G in serum and amniotic fluid, as well as fetal biometric data and placental volume and perfusion indices, were determined in 41 singleton pregnancies with no complications. The level of sHLA-G (U/mL) was tested with a sandwich enzyme-linked immunosorbent assay (ELISA) kit. Results: The sHLA-G levels were unchanged both in amniotic fluid and serum during mid-pregnancy. The sHLA-G level in serum correlated positively with amniotic sHLA-G level (β = 0.63, p < 0.01). Serum sHLA-G level was significantly correlated with abdominal measurements (β = 0.41, p < 0.05) and estimated fetal weight (β = 0.41, p < 0.05). Conversely, amniotic sHLA-G level and placental perfusion (VI: β = −0.34, p < 0.01 and VFI: β = −0.44, p < 0.01, respectively) were negatively correlated. A low amniotic sHLA-G level was significantly associated with nuchal translucency (r = −0.102, p < 0.05). Conclusions: sHLA-G assayed in amniotic fluid might be a potential indicator of placental function, whereas the sHLA-G level in serum can be a prognostic factor for feto-placental insufficiency. | |
| 650 | 4 | |a Klinikai orvostan | |
| 700 | 0 | 1 | |a Sikovanyecz János Sebestyén |e aut |
| 700 | 0 | 1 | |a Földesi Imre |e aut |
| 700 | 0 | 1 | |a Surányi Andrea |e aut |
| 700 | 0 | 1 | |a Várbíró Szabolcs |e aut |
| 700 | 0 | 1 | |a Németh Gábor László |e aut |
| 700 | 0 | 1 | |a Kozinszky Zoltán |e aut |
| 700 | 0 | 1 | |a Sikovanyecz János |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/35397/1/bioengineering-11-00509.pdf |z Dokumentum-elérés |