Methotrexate γ-hydroxamate derivatives as potential dual target antitumor drugs
A series of new aminopteroyl-based hydroxamate derivatives were synthesized and tested in vitro in cell culture models as potential dual target drugs. These compounds were designed to target two families of enzymes, matrix metalloproteinases (MMP) and a folate enzyme, dihydrofolate reductase (DHFR)....
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2007
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| Sorozat: | BIOORGANIC & MEDICINAL CHEMISTRY
15 No. 3 |
| Tárgyszavak: | |
| doi: | 10.1016/j.bmc.2006.11.017 |
| mtmt: | 1074898 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/34369 |