Alkoxyalkylation of Electron-Rich Aromatic Compounds
Alkoxyalkylation and hydroxyalkylation methods utilizing oxo-compound derivatives such as aldehydes, acetals or acetylenes and various alcohols or water are widely used tools in preparative organic chemistry to synthesize bioactive compounds, biosensors, supramolecular compounds and petrochemicals....
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2024
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
25 No. 13 |
| Tárgyszavak: | |
| doi: | 10.3390/ijms25136966 |
| mtmt: | 35074742 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/33697 |
| LEADER | 01897nab a2200253 i 4500 | ||
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| 005 | 20240710113931.0 | ||
| 008 | 240701s2024 hu o 000 eng d | ||
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| 024 | 7 | |a 10.3390/ijms25136966 |2 doi | |
| 024 | 7 | |a 35074742 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a eng | ||
| 100 | 1 | |a Simon Péter | |
| 245 | 1 | 0 | |a Alkoxyalkylation of Electron-Rich Aromatic Compounds |h [elektronikus dokumentum] / |c Simon Péter |
| 260 | |c 2024 | ||
| 300 | |a 34 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 25 No. 13 | |
| 520 | 3 | |a Alkoxyalkylation and hydroxyalkylation methods utilizing oxo-compound derivatives such as aldehydes, acetals or acetylenes and various alcohols or water are widely used tools in preparative organic chemistry to synthesize bioactive compounds, biosensors, supramolecular compounds and petrochemicals. The syntheses of such molecules of broad relevance are facilitated by acid, base or heterogenous catalysis. However, degradation of the N-analogous Mannich bases are reported to yield alkoxyalkyl derivatives via the retro-Mannich reaction. The mutual derivative of all mentioned species are quinone methides, which are reported to form under both alkoxy- and aminoalkylative conditions and via the degradation of the Mannich-products. The aim of this review is to summarize the alkoxyalkylation (most commonly alkoxymethylation) of electron-rich arenes sorted by the methods of alkoxyalkylation (direct or via retro-Mannich reaction) and the substrate arenes, such as phenolic and derived carbocycles, heterocycles and the widely examined indole derivatives. | |
| 650 | 4 | |a Kémiai tudományok | |
| 650 | 4 | |a Általános orvostudomány | |
| 700 | 0 | 1 | |a Lőrinczi Bálint |e aut |
| 700 | 0 | 1 | |a Szatmári István |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/33697/1/IntJMolSci_6966_Simon_2024.pdf |z Dokumentum-elérés |