Antibodies to calcium channels from ALS patients passively transferred to mice selectively increase intracellular calcium and induce ultrastructural changes in motoneurons.
Antibodies to Ca channels in ALS patients IgG can be demonstrated to enhance Ca current and cause cell injury and death in a motoneuron cell line in vitro. To determine whether these antibodies can alter neuronal calcium homeostasis in vivo IgG fractions from six ALS patients were injected intraperi...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
1995
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| Sorozat: | SYNAPSE
20 No. 3 |
| Tárgyszavak: | |
| doi: | 10.1002/syn.890200302 |
| mtmt: | 1314827 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/32439 |