rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Light chain deposition nephropathy in necropsy material [Leichtketten-Nephropathie im Obduktionsgut]
  name:
    name part: Iványi Béla
    role:
      role term: creator
  name:
    name part: Varga Gy.
    role:
      role term: aut
  name:
    name part: Nagy Judit
    role:
      role term: aut
  name:
    name part: Berkessy S.
    role:
      role term: aut
  name:
    name part: Keresztury S.
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: hu
    date issued: 1991
    issuance: continuing
  language:
    language term: eng
  physical description:
    form: elektronikus dokumentum
    extent: 366-371
  abstract: The clinical and necropsy findings on 7 patients with monoclonal immunoglobulin light chain deposition nephropathy are described (4 cases with a myelomatous and 3 with a non-myelomatous background). All patients had moderate proteinuria and progressive azotemia. Three myelomatous and all three non-myelomatous patients died from uremia after a mean time of 12 and 23 months, respectively, from the first presentation. Immunohistochemically, 6 patients had kappa, and one had lambda light chain deposition. Light microscopically, interstitial fibrosis, tubular atrophy and arteriolar hyalinosis were present in all cases. The glomeruli showed no changes (1 case), or displayed patterns of mesangial widening: mild (1 case), nodular (mesangial nodules, 4 cases) or global lobular expansion (1 case). Mesangial nodules were observed either with or without lamellation. Around the nodules, microaneurysms were seen in 2 cases. Mesangial nodular expansion was accompanied by crescents in 56% of the glomeruli in a male patient suffering from kappa light chain deposition nephropathy without myeloma. The present findings and a review of the literature indicate the following mesangial changes in light chain deposition nephropathy: 1. no changes, 2. mild expansion, 3. nodular expansion with and without lamellation, and 4. lobular expansion. Subtypes 2, 3 and 4 may be present in parallel, may occur with or without cellular proliferation, and may be accompanied by crescents. The term nodular glomerulosclerosis to describe mesangial nodular expansion is not completely correct, and hence its use is not recommended.
  note: Iványi Béla
  subject:
    topic: Általános orvostudomány
  subject:
    topic: Egyéb orvostudományok
  related item:
    title info:
      title: ZENTRALBLATT FÜR PATHOLOGIE 137 No. 4
  identifier: 0863-4106
  identifier: http://publicatio.bibl.u-szeged.hu/32345/1/aok_klny_297_91.pdf
  record info:
    record content source: SZTE Publicatio Repozitórium
    record creation date: 250401
    record change date: 20250401095317.0
    record identifier: publ32345
    language of cataloging:
      language term: hun