02433nab a2200253 i 4500 publ31965 20250317093645.0 250317s1994 hu o 000 eng d 1073-2322 10.1097/00024382-199412000-00005 doi 1320997 mtmt SZTE Publicatio Repozitórium hun eng Kaszaki József Role of histamine in the intestinal flow response following mesenteric ischemia [elektronikus dokumentum] / Kaszaki József 1994 413-420 SHOCK 2 No. 6 Sudden reperfusion of the gut following prolonged ischemia can itself have more deleterious consequences than the ischemia alone. Studies of vasodilator factors influencing the increased flow on reperfusion are therefore of importance. In the present study, a possible role of histamine in the postischemic flow response was examined after a period of total segmental ischemia. The artery supplying the terminal ileum was occluded in anesthetized dogs. Ischemia of 30 min duration was followed by a 30 min reperfusion period (control postischemic flow response), and the arterial blood flow to the segment was measured. After the control postischemic flow response, one of the following drugs was administered intravenously: histamine H-1- or H-2-blockers (tripelennamine, .5 mg/kg, cimetidine, 10 mg/kg, ranitidine, 2 mg/kg), cromolyn (a mast cell stabilizer, 25 mg/kg), and aminoguanidine (a diamine oxidase blocker, 50 mg/kg). The 30 min ischemia-30 min reperfusion cycle was then repeated (test postischemic flow response). A 30 min mesenteric ischemia-reperfusion period is reproducible once without a significant change in its hemodynamic parameters. The duration and volume of the postischemic flow response were significantly decreased by cimetidine, ranitidine, or cromolyn, and were increased by aminoguanidine. Tripelennamine did not affect the postischemic vasodilatator response. At the onset of reperfusion, a release of endogenous histamine occurs from the gut, originating mainly from mast cells. It is proposed that histamine participates in the postischemic flow response through the H-2-receptors. Klinikai orvostan Boros Mihály aut Szabó Andrea aut Nagy Sándor aut http://publicatio.bibl.u-szeged.hu/31965/1/aok_klny_54_94.pdf Dokumentum-elérés