rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Electrophysiologic effects of detajmium on isolated dog cardiac ventricular and Purkinje fibers
  name:
    name part: Hála Ottó
    role:
      role term: creator
  name:
    name part: Németh Miklós
    role:
      role term: aut
  name:
    name part: Varró András
    role:
      role term: aut
  name:
    name part: Papp Gyula
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: hu
    date issued: 1994
    issuance: continuing
  language:
    language term: eng
  physical description:
    form: elektronikus dokumentum
    extent: 559-565
  abstract: We studied the electrophysiologic effects of the antiarrhythmic compound detajmium (Tachmalcor) on isolated dog and rabbit cardiac preparations, applying the conventional intracellular microelectrode techniques. In dog ventricular muscle fibers (37 degrees C, stimulation frequency 1 Hz), 1 mu M detajmium did not change resting potential (RP), action potential amplitude (APA), AP duration measured at 90% of repolarization (APD(90)), or effective refractory period (ERP) significantly, but reduced maximum rate of depolarization (V-max) significantly from 236.7 +/- 28.9 to 177.3 +/- 22.5 V/s (n = 6, p < 0.01). In dog Purkinje fibers (37 degrees C, stimulation frequency 1 Hz), 1 mu M detajmium significantly decreased APA from 111.1 +/- 12.3 to 100.0 +/- 2.5 mV (n = 8, p < 0.003), APD(90) from 359.0 +/- 17.5 to 262.1 +/- 12.3 ms (n = 8, p < 0.001) and V-max, from 687.5 +/- 57.2 to 523.7 +/- 58.2 V/s (n = 8, p < 0.001) without changing maximal diastolic potential or ERP/ APD ratio significantly. The effect of detajmium on V-max in both dog ventricular muscle and Purkinje fibers was frequency dependent. Fractional V-max block was 0.185 +/- 0.008 1/AP. The recovery kinetics of V-max (offset kinetics) was extremely slow (time constant = 348.16 +/- 57.43 s) considerably slower than most of those of other antiarrhythmic drugs yet reported. Detajmium in concentration <32 mu M did not influence the beta-adrenoceptors or slow response APs in dog ventricular tissue significantly. On the basis of its electrophysiologic effects, detajmium, like prajmaline, encainide, or flecainide, can be best classified as a class I/C antiarrhythmic drug according to the Vaughan Williams' classification scheme.
  note: Hála Ottó
  subject:
    topic: Általános orvostudomány
  subject:
    topic: Klinikai orvostan
  related item:
    title info:
      title: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 24 No. 4
  identifier: 0160-2446
  identifier: http://publicatio.bibl.u-szeged.hu/31959/1/aok_klny_37_94.pdf
  record info:
    record content source: SZTE Publicatio Repozitórium
    record creation date: 250314
    record change date: 20250314105323.0
    record identifier: publ31959
    language of cataloging:
      language term: hun