Role of Hippocampal CA2 Region in Triggering Sharp-Wave Ripples
Sharp-wave ripples (SPW-Rs) in the hippocampus are implied in memory consolidation, as shown by observational and interventional experiments. However, the mechanism of their generation remains unclear. Using two-dimensional silicon probe arrays, we investigated the propagation of SPW-Rs across the h...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | NEURON
91 No. 6 |
| Tárgyszavak: | |
| doi: | 10.1016/j.neuron.2016.08.008 |
| mtmt: | 3117606 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/27677 |
| LEADER | 01685nab a2200253 i 4500 | ||
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| 005 | 20230629081816.0 | ||
| 008 | 230629s2016 hu o 0|| Angol d | ||
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| 024 | 7 | |a 10.1016/j.neuron.2016.08.008 |2 doi | |
| 024 | 7 | |a 3117606 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Oliva Azahara | |
| 245 | 1 | 0 | |a Role of Hippocampal CA2 Region in Triggering Sharp-Wave Ripples |h [elektronikus dokumentum] / |c Oliva Azahara |
| 260 | |c 2016 | ||
| 300 | |a 1342-1355 | ||
| 490 | 0 | |a NEURON |v 91 No. 6 | |
| 520 | 3 | |a Sharp-wave ripples (SPW-Rs) in the hippocampus are implied in memory consolidation, as shown by observational and interventional experiments. However, the mechanism of their generation remains unclear. Using two-dimensional silicon probe arrays, we investigated the propagation of SPW-Rs across the hippocampal CA1, CA2, and CA3 subregions. Synchronous activation of CA2 ensembles preceded SPW-R-related population activity in CA3 and CA1 regions. Deep CA2 neurons gradually increased their activity prior to ripples and were suppressed during the population bursts of CA3-CA1 neurons (ramping cells). Activity of superficial CA2 cells preceded the activity surge in CA3-CA1 (phasic cells). The trigger role of the CA2 region in SPW-R was more pronounced during waking than sleeping. These results point to the CA2 region as an initiation zone for SPW-Rs. | |
| 650 | 4 | |a Általános orvostudomány | |
| 700 | 0 | 2 | |a Fernandez-Ruiz Antonio |e aut |
| 700 | 0 | 2 | |a Buzsáki György |e aut |
| 700 | 0 | 2 | |a Berényi Antal |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/27677/1/PIIS0896627316305001.pdf |z Dokumentum-elérés |