Antiarrhythmic and Inotropic Effects of Selective Na+/Ca2+ Exchanger Inhibition What Can We Learn from the Pharmacological Studies? /
Life-long stable heart function requires a critical balance of intracellular Ca2+. Several ion channels and pumps cooperate in a complex machinery that controls the influx, release, and efflux of Ca2+. Probably one of the most interesting and most complex players of this crosstalk is the Na+/Ca2+ ex...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2022
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
23 No. 23 |
| Tárgyszavak: | |
| doi: | 10.3390/ijms232314651 |
| mtmt: | 33271845 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/25672 |
| LEADER | 02183nab a2200241 i 4500 | ||
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| 001 | publ25672 | ||
| 005 | 20221201121826.0 | ||
| 008 | 221201s2022 hu o 0|| Angol d | ||
| 022 | |a 1661-6596 | ||
| 024 | 7 | |a 10.3390/ijms232314651 |2 doi | |
| 024 | 7 | |a 33271845 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Nagy Norbert | |
| 245 | 1 | 0 | |a Antiarrhythmic and Inotropic Effects of Selective Na+/Ca2+ Exchanger Inhibition |h [elektronikus dokumentum] : |b What Can We Learn from the Pharmacological Studies? / |c Nagy Norbert |
| 260 | |c 2022 | ||
| 300 | |a 22 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 23 No. 23 | |
| 520 | 3 | |a Life-long stable heart function requires a critical balance of intracellular Ca2+. Several ion channels and pumps cooperate in a complex machinery that controls the influx, release, and efflux of Ca2+. Probably one of the most interesting and most complex players of this crosstalk is the Na+/Ca2+ exchanger, which represents the main Ca2+ efflux mechanism; however, under some circumstances, it can also bring Ca2+ into the cell. Therefore, the inhibition of the Na+/Ca2+ exchanger has emerged as one of the most promising possible pharmacological targets to increase Ca2+ levels, to decrease arrhythmogenic depolarizations, and to reduce excessive Ca2+ influx. In line with this, as a response to increasing demand, several more or less selective Na+/Ca2+ exchanger inhibitor compounds have been developed. In the past 20 years, several results have been published regarding the effect of Na+/Ca2+ exchanger inhibition under various circumstances, e.g., species, inhibitor compounds, and experimental conditions; however, the results are often controversial. Does selective Na+/Ca2+ exchanger inhibition have any future in clinical pharmacological practice? In this review, the experimental results of Na+/Ca2+ exchanger inhibition are summarized focusing on the data obtained by novel highly selective inhibitors. | |
| 650 | 4 | |a Orvosi biotechnológia | |
| 700 | 0 | 1 | |a Tóth Noémi |e aut |
| 700 | 0 | 1 | |a Nánási Péter Pál |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/25672/1/NagyN2022.pdf |z Dokumentum-elérés |