Distal Versus Conventional Radial Access for Coronary Angiography and Intervention The DISCO RADIAL Trial

BACKGROUND Currently, transradial access (TRA) is the recommended access for coronary procedures because of increased safety, with radial artery occlusion (RAO) being its most frequent complication, which will increasingly affect patients undergoing multiple procedures during their lifetimes. Recent...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Aminian Adel
Sgueglia Gregory A.
Wiemer Marcus
Kefer Joelle
Gasparini Gabriele L.
Ruzsa Zoltán
van Leeuwen Maarten A.H
Ungureanu Claudiu
Leibundgut Gregor
Vandeloo Bert
Kedev Sasko
Bernat Ivo
Ratib Karim
Iglesias Juan F.
Kákonyi Kornél
Dokumentumtípus: Cikk
Megjelent: 2022
Sorozat:JACC-CARDIOVASCULAR INTERVENTIONS 15 No. 12
Tárgyszavak:
doi:10.1016/j.jcin.2022.04.032

mtmt:33056371
Online Access:http://publicatio.bibl.u-szeged.hu/24989
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520 3 |a BACKGROUND Currently, transradial access (TRA) is the recommended access for coronary procedures because of increased safety, with radial artery occlusion (RAO) being its most frequent complication, which will increasingly affect patients undergoing multiple procedures during their lifetimes. Recently, distal radial access (DRA) has emerged as a promising alternative access to minimize RAO risk. A large-scale, international, randomized trial comparing RAO with TRA and DRA is lacking. OBJECTIVES The aim of this study was to assess the superiority of DRA compared with conventional TRA with respect to forearm RAO. METHODS DISCO RADIAL (Distal vs Conventional Radial Access) was an international, multicenter, randomized controlled trial in which patients with indications for percutaneous coronary procedure using a 6-F Slender sheath were randomized to DRA or TRA with systematic implementation of best practices to reduce RAO. The primary endpoint was the incidence of forearm RAO assessed by vascular ultrasound at discharge. Secondary endpoints include crossover, hemostasis time, and access site-related complications. RESULTS Overall, 657 patients underwent TRA, and 650 patients underwent DRA. Forearm RAO did not differ between groups (0.91% vs 0.31%; P = 0.29). Patent hemostasis was achieved in 94.4% of TRA patients. Crossover rates were higher with DRA (3.5% vs 7.4%; P = 0.002), and median hemostasis time was shorter (180 vs 153 minutes; P < 0.001). Radial artery spasm occurred more with DRA (2.7% vs 5.4%; P = 0.015). Overall bleeding events and vascular complications did not differ between groups. CONCLUSIONS With the implementation of a rigorous hemostasis protocol, DRA and TRA have equally low RAO rates. DRA is associated with a higher crossover rate but a shorter hemostasis time. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. 
650 4 |a Klinikai orvostan 
700 0 1 |a Sgueglia Gregory A.  |e aut 
700 0 1 |a Wiemer Marcus  |e aut 
700 0 1 |a Kefer Joelle  |e aut 
700 0 1 |a Gasparini Gabriele L.  |e aut 
700 0 1 |a Ruzsa Zoltán  |e aut 
700 0 2 |a van Leeuwen Maarten A.H.  |e aut 
700 0 2 |a Ungureanu Claudiu  |e aut 
700 0 2 |a Leibundgut Gregor  |e aut 
700 0 2 |a Vandeloo Bert  |e aut 
700 0 2 |a Kedev Sasko  |e aut 
700 0 2 |a Bernat Ivo  |e aut 
700 0 2 |a Ratib Karim  |e aut 
700 0 2 |a Iglesias Juan F.  |e aut 
700 0 2 |a Kákonyi Kornél  |e aut 
856 4 0 |u http://publicatio.bibl.u-szeged.hu/24989/1/Aminian2022.pdf  |z Dokumentum-elérés