Kappa free light chains is a valid tool in the diagnostics of MS A large multicenter study /
To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS).We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligocl...
Elmentve itt :
| Szerzők: | |
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2020
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| Sorozat: | MULTIPLE SCLEROSIS JOURNAL
26 No. 8 |
| Tárgyszavak: | |
| doi: | 10.1177/1352458519845844 |
| mtmt: | 31040420 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/24521 |
| LEADER | 02452nab a2200385 i 4500 | ||
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| 008 | 220613s2020 hu o 0|| Angol d | ||
| 022 | |a 1352-4585 | ||
| 024 | 7 | |a 10.1177/1352458519845844 |2 doi | |
| 024 | 7 | |a 31040420 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a Angol | ||
| 100 | 1 | |a Leurs C. E. | |
| 245 | 1 | 0 | |a Kappa free light chains is a valid tool in the diagnostics of MS |h [elektronikus dokumentum] : |b A large multicenter study / |c Leurs C. E. |
| 260 | |c 2020 | ||
| 300 | |a 912-923 | ||
| 490 | 0 | |a MULTIPLE SCLEROSIS JOURNAL |v 26 No. 8 | |
| 520 | 3 | |a To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS).We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off for KFLC and LFLC indexes.The cut-off for the KFLC index was 6.6 (95% confidence interval (CI) = 5.2-138.1). The cut-off for the LFLC index was 6.9 (95% CI = 4.5-22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI = 0.85-0.90) was higher than OCB (0.82; 95%CI = 0.79-0.85; p < 0.001), but specificity (0.83; 95% CI = 0.78-0.88) was lower (OCB = 0.92; 95% CI = 0.89-0.96; p < 0.001). Both sensitivity and specificity for the LFLC index were lower than OCB.Compared with OCB, the KFLC index is more sensitive but less specific for diagnosing CIS/MS. Lacking an elevated KFLC index is more powerful for excluding MS compared with OCB but the latter is more important for ruling in a diagnosis of CIS/MS. | |
| 650 | 4 | |a Idegtudományok (benne pszichofiziológia) | |
| 700 | 0 | 1 | |a Twaalfhoven Ham |e aut |
| 700 | 0 | 2 | |a Lissenberg-Witte B. I. |e aut |
| 700 | 0 | 2 | |a van Pesch V. |e aut |
| 700 | 0 | 2 | |a Dujmovic I. |e aut |
| 700 | 0 | 2 | |a Drulovic J. |e aut |
| 700 | 0 | 2 | |a Castellazzi M. |e aut |
| 700 | 0 | 2 | |a Bellini T. |e aut |
| 700 | 0 | 2 | |a Pugliatti M. |e aut |
| 700 | 0 | 2 | |a Kuhle J. |e aut |
| 700 | 0 | 2 | |a Villar L. M. |e aut |
| 700 | 0 | 2 | |a Alvarez-Cermeño J. C. |e aut |
| 700 | 0 | 2 | |a Vécsei László |e aut |
| 700 | 0 | 2 | |a Rajda Cecília |e aut |
| 700 | 0 | 2 | |a Fazekas F. |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/24521/1/Kappafreelightchains.pdf |z Dokumentum-elérés |