HLA-DQ2 homozygosis increases tTGA levels at diagnosis but does not influence the clinical phenotype of coeliac disease A multicentre study /

Magnitude of gluten-specific T-cell responses in coeliac disease (CD) might be dependent on HLA-DQ2 gene dose. We aimed to investigate the effects of HLA-DQB1*02 allele dose on clinical outcomes.We reviewed the charts of all coeliac patients attending to three Hungarian university clinics after 1997...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Bajor Judit
Szakács Zsolt
Juhász Márk
Papp Mária
Kocsis Dorottya
Szegedi Éva
Földi Ildikó
Borbásné Farkas Kornélia
Hegyi Péter
Vincze Áron
Dokumentumtípus: Cikk
Megjelent: 2019
Sorozat:INTERNATIONAL JOURNAL OF IMMUNOGENETICS 46 No. 2
doi:10.1111/iji.12415

mtmt:30449576
Online Access:http://publicatio.bibl.u-szeged.hu/22004
Leíró adatok
Tartalmi kivonat:Magnitude of gluten-specific T-cell responses in coeliac disease (CD) might be dependent on HLA-DQ2 gene dose. We aimed to investigate the effects of HLA-DQB1*02 allele dose on clinical outcomes.We reviewed the charts of all coeliac patients attending to three Hungarian university clinics after 1997 and included those patients, who (a) were diagnosed with CD, (b) underwent high-resolution HLA typing and (c) were ≥18 years at the time of data collection. HLA typing was performed to determine DQB1*02 allele dose. Patients were divided into risk groups by DQB1*02 allele dose, as follows: high-, intermediate- and low-risk groups corresponded to a double, single and zero doses, respectively. We used ANOVA and Pearson's chi-squared test to explore association between HLA risk and clinical variables.A total of 727 coeliac patients attended the clinics but only 105 (14.4%) patients were eligible for inclusion. High, intermediate and low HLA risk patients comprised 35.3%, 52.3% and 12.3% of the study population, respectively. Double dose of HLA-DQB1*02 was more frequent in patient with high tTGA level (>10 times the upper limit of normal; p = 0.045). Gene dose was not associated with younger age at diagnosis (p = 0.549), gender (p = 0.739), more severe diagnostic histology (p = 0.318), more frequent classical presentation (p = 0.846), anaemia (p = 0.611), metabolic bone disease (p = 0.374), dermatitis herpetiformis (p = 0.381) and autoimmune diseases (p = 0.837).Our study shows a significant gene dose effect in terms of tTGA level at diagnosis, but no significant association between HLA-DQB1*02 allele dose and the clinical outcomes in CD.
Terjedelem/Fizikai jellemzők:74-81
ISSN:1744-3121