Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier
The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (some-times called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. They constitute a cr...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2021
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
22 No. 9 |
| doi: | 10.3390/ijms22094677 |
| mtmt: | 32000799 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/21392 |
| LEADER | 01752nab a2200217 i 4500 | ||
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| 005 | 20210507145135.0 | ||
| 008 | 210507s2021 hu o 0|| zxx d | ||
| 022 | |a 1661-6596 | ||
| 024 | 7 | |a 10.3390/ijms22094677 |2 doi | |
| 024 | 7 | |a 32000799 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Danis Judit | |
| 245 | 1 | 0 | |a Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier |h [elektronikus dokumentum] / |c Danis Judit |
| 260 | |c 2021 | ||
| 300 | |a Terjedelem: 18-Azonosító: 4677 | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 22 No. 9 | |
| 520 | 3 | |a The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (some-times called the NOD-like receptors, though the family contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress and microbial infection. They constitute a critical arm of the innate immune response, though their functions are not restricted to pathogen recognition and members engage in controlling inflammasome activation, antigen-presentation, transcriptional regulation, cell death and also embryogenesis. NLRs are found from basal metazoans to plants, to zebrafish, mice and humans though functions of individual members can vary from species to species. NLRs also display highly wide-ranging tissue expression. Here, we discuss the importance of NLRs to the immune response at the epidermal barrier and summarise the known role of individual family members in the pathogenesis of skin disease. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | |
| 700 | 0 | 1 | |a Mellett Mark |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/21392/1/ijms-22-04677-v2.pdf |z Dokumentum-elérés |