The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07
Chalcones belong to a class of biologically active polyphenolic natural products. As a result of their simple chemical nature, they are easily synthesized and show a variety of promising biological activities. 2-Hydroxy-4 '-methoxychalcone (AN07) is a synthetic chalcone derivate with potential...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2020
|
| Sorozat: | MOLECULES
25 No. 12 |
| doi: | 10.3390/molecules25122907 |
| mtmt: | 31500739 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/19467 |
| LEADER | 03142nab a2200289 i 4500 | ||
|---|---|---|---|
| 001 | publ19467 | ||
| 005 | 20200911094649.0 | ||
| 008 | 200911s2020 hu o 0|| zxx d | ||
| 022 | |a 1420-3049 | ||
| 024 | 7 | |a 10.3390/molecules25122907 |2 doi | |
| 024 | 7 | |a 31500739 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Chen Yih-Fung | |
| 245 | 1 | 4 | |a The Antioxidant, Anti-Inflammatory, and Neuroprotective Properties of the Synthetic Chalcone Derivative AN07 |h [elektronikus dokumentum] / |c Chen Yih-Fung |
| 260 | |c 2020 | ||
| 300 | |a Azonosító: 2907-Terjedelem: 20 p | ||
| 490 | 0 | |a MOLECULES |v 25 No. 12 | |
| 520 | 3 | |a Chalcones belong to a class of biologically active polyphenolic natural products. As a result of their simple chemical nature, they are easily synthesized and show a variety of promising biological activities. 2-Hydroxy-4 '-methoxychalcone (AN07) is a synthetic chalcone derivate with potential anti-atherosclerosis effects. In this study, we demonstrated the novel antioxidant, anti-inflammatory, and neuroprotective effects of AN07. In RAW 264.7 macrophages, AN07 attenuated lipopolysaccharide (LPS)-induced elevations in reactive oxygen species (ROS) level and oxidative stress via down-regulating gp91(phox)expression and stimulating the antioxidant system of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) pathways, which were accompanied by increased glutathione (GSH) levels. Additionally, AN07 attenuated LPS-induced inflammatory factors, including NO, inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and phosphorylated inhibitor of nuclear factor kappa B-alpha (p-I kappa B alpha) in RAW 264.7 macrophages. However, the effects of AN07 on promoting nuclear Nrf2 levels and decreasing COX-2 expressions were significantly abrogated by the peroxisome proliferator-activated receptor-gamma (PPAR gamma) antagonist GW9662. In human dopaminergic SH-SY5Y cells treated with or without methylglyoxal (MG), a toxic endogenous by-product of glycolysis, AN07 up-regulated neurotrophic signals including insulin-like growth factor 1 receptor (IGF-1R),p-Akt,p-GSK3 beta, glucagon-like peptide 1 receptor (GLP-1R), and brain-derived neurotrophic factor (BDNF). AN07 attenuated MG-induced apoptosis by up-regulating the B-cell lymphoma 2 (Bcl-2) protein and down-regulating the cytosolic expression of cytochrome c. AN07 also attenuated MG-induced neurite damage via down-regulating the Rho-associated protein kinase 2 (ROCK2)/phosphorylated LIM kinase 1 (p-LIMK1) pathway. Moreover, AN07 ameliorated the MG-induced down-regulation of neuroprotective Parkinsonism-associated proteinsparkin,pink1, andDJ-1. These findings suggest that AN07 possesses the potentials to be an anti-inflammatory, antioxidant, and neuroprotective agent | |
| 700 | 0 | 1 | |a Wu Sheng-Nan |e aut |
| 700 | 0 | 1 | |a Gao Jia-Mao |e aut |
| 700 | 0 | 1 | |a Liao Zhi-Yao |e aut |
| 700 | 0 | 1 | |a Tseng Yu-Ting |e aut |
| 700 | 0 | 1 | |a Fülöp Ferenc |e aut |
| 700 | 0 | 1 | |a Chang Fang-Rong |e aut |
| 700 | 0 | 1 | |a Lo Yi-Ching |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/19467/1/molecules-25-02907.pdf |z Dokumentum-elérés |