Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus
A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2018
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| Sorozat: | PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
31 No. 3 |
| mtmt: | 3370144 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/19432 |
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| 100 | 1 | |a Rauf Abdur | |
| 245 | 1 | 0 | |a Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus |h [elektronikus dokumentum] / |c Rauf Abdur |
| 260 | |c 2018 | ||
| 300 | |a 821-825 | ||
| 490 | 0 | |a PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES |v 31 No. 3 | |
| 520 | 3 | |a A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Molecular docking of compound 1 revealed the correlation between in-silico with in-vitro results. The molecular docking results showed that compound 1 is bind closely where co-crystal ligand of P-gp is present. But usually, computational investigation predicts that, if a compound gives lesser score then compound will exhibit good activity. Hence, the docking scores of compound 1 are the near to the Rhodamine. It is conclude that there are certain important structural features of compound 1which are responsible for the inhibiting potency of P-gp from mice. The computational Petra/Osiris/Molinspiration (POM) analysis confirms the possibility of use of compound 1 without side effect or less toxicity risks. | |
| 700 | 0 | 1 | |a Shaheen Usama Y. |e aut |
| 700 | 0 | 1 | |a Raza Muslim |e aut |
| 700 | 0 | 1 | |a Uddin Ghias |e aut |
| 700 | 0 | 2 | |a Hadda, Ben Taibi |e aut |
| 700 | 0 | 2 | |a Mabkhot Yahia Nasser |e aut |
| 700 | 0 | 2 | |a Jehan Noor |e aut |
| 700 | 0 | 2 | |a Ahmad Bashir |e aut |
| 700 | 0 | 2 | |a Raza Saleem |e aut |
| 700 | 0 | 2 | |a Molnár József |e aut |
| 700 | 0 | 2 | |a Csonka Ákos |e aut |
| 700 | 0 | 2 | |a Szabó Diána |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/19432/1/3370144_MultidrugResistanceReversalActivityofextractandARareDimericNaphthoquinonefromDiospyroslotus.pdf |z Dokumentum-elérés |