Isolation and Structure Elucidation, Molecular Docking Studies of Screlotiumol from Soil Borne Fungi Screlotium rolfsii and their Reversal of Multidrug Resistance in Mouse Lymphoma Cells
A new compound namely (13-(3,3-dihydroxypropyl)-1,6-dihydroxy-3,4-dihydro-1H-isochromen-8(5H)-one (1) was isolated from an ethyl acetate extract of the borne fungi Screlotium rolfsii. Its chemical structure was elucidated by spectroscopic analysis. Screlotiumol 1 were evaluated for their effects on...
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2016
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| Sorozat: | ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
17 No. 4 |
| doi: | 10.7314/APJCP.2016.17.4.2083 |
| mtmt: | 3073568 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/19427 |
| LEADER | 02263nab a2200301 i 4500 | ||
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| 024 | 7 | |a 10.7314/APJCP.2016.17.4.2083 |2 doi | |
| 024 | 7 | |a 3073568 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Ahmad Bashir | |
| 245 | 1 | 0 | |a Isolation and Structure Elucidation, Molecular Docking Studies of Screlotiumol from Soil Borne Fungi Screlotium rolfsii and their Reversal of Multidrug Resistance in Mouse Lymphoma Cells |h [elektronikus dokumentum] / |c Ahmad Bashir |
| 260 | |c 2016 | ||
| 300 | |a 2083-2087 | ||
| 490 | 0 | |a ASIAN PACIFIC JOURNAL OF CANCER PREVENTION |v 17 No. 4 | |
| 520 | 3 | |a A new compound namely (13-(3,3-dihydroxypropyl)-1,6-dihydroxy-3,4-dihydro-1H-isochromen-8(5H)-one (1) was isolated from an ethyl acetate extract of the borne fungi Screlotium rolfsii. Its chemical structure was elucidated by spectroscopic analysis. Screlotiumol 1 were evaluated for their effects on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein (P-gp) of the soil borne fungi. The multidrug resistant P-glycoprotein is a target for chemotherapeutic drugs in cancer cells. In the present study rhodamine-123 exclusion screening test on human mdr1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma which showed excellent MDR reversing effect in a dose dependent manner against mouse T-lymphoma cell line. Moreover, molecular docking studies of compound-1 also showed better results as compared with the standard. Therefore the preliminary results obtained from this study suggest that screlotiumol 1 could be used as a potential agent for the treatment of cancer. | |
| 700 | 0 | 1 | |a Rizwan Muhammad |e aut |
| 700 | 0 | 1 | |a Rauf Abdur |e aut |
| 700 | 0 | 1 | |a Raza Muslim |e aut |
| 700 | 0 | 1 | |a Azam Sadiq |e aut |
| 700 | 0 | 1 | |a Bashir Shumaila |e aut |
| 700 | 0 | 1 | |a Molnár József |e aut |
| 700 | 0 | 1 | |a Csonka Ákos |e aut |
| 700 | 0 | 1 | |a Szabó Diána |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/19427/1/3073568_IsolationandStructureElucidationMolecularDockingStudiesofScrelotiumolfromSoilBorneFungiScrelotiumrolfsiiandtheirReversalofMultidrugResistanceinMouseLymphomaCells.pdf |z Dokumentum-elérés |