TRP Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches
Pain in trigeminal areas is driven by nociceptive trigeminal afferents. Transduction molecules, among them the nonspecific cation channels transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1), which are activated by endogenous and exogenous ligands, are expressed by a significant p...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2020
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| Sorozat: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
21 No. 1 |
| doi: | 10.3390/ijms21010342 |
| mtmt: | 31134914 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/18880 |
| LEADER | 02116nab a2200229 i 4500 | ||
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| 005 | 20200610121843.0 | ||
| 008 | 200610s2020 hu o 0|| zxx d | ||
| 022 | |a 1661-6596 | ||
| 024 | 7 | |a 10.3390/ijms21010342 |2 doi | |
| 024 | 7 | |a 31134914 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Dux Mária | |
| 245 | 1 | 0 | |a TRP Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches |h [elektronikus dokumentum] / |c Dux Mária |
| 260 | |c 2020 | ||
| 300 | |a Azonosíító: 342-Terjedelem: 23 p | ||
| 490 | 0 | |a INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |v 21 No. 1 | |
| 520 | 3 | |a Pain in trigeminal areas is driven by nociceptive trigeminal afferents. Transduction molecules, among them the nonspecific cation channels transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1), which are activated by endogenous and exogenous ligands, are expressed by a significant population of trigeminal nociceptors innervating meningeal tissues. Many of these nociceptors also contain vasoactive neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P. Release of neuropeptides and other functional properties are frequently examined using the cell bodies of trigeminal neurons as models of their sensory endings. Pathophysiological conditions cause phosphorylation, increased expression and trafficking of transient receptor potential (TRP) channels, neuropeptides and other mediators, which accelerate activation of nociceptive pathways. Since nociceptor activation may be a significant pathophysiological mechanism involved in both peripheral and central sensitization of the trigeminal nociceptive pathway, its contribution to the pathophysiology of primary headaches is more than likely. Metabolic disorders and medication-induced painful states are frequently associated with TRP receptor activation and may increase the risk for primary headaches. | |
| 700 | 0 | 1 | |a Rosta Judit |e aut |
| 700 | 0 | 1 | |a Messlinger Karl |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/18880/1/DuxM_IntJMolSci_2020.pdf |z Dokumentum-elérés |