Periodic Nucleation of Calcium Phosphate in a Stirred Biocatalytic Reaction
Highly ordered superstructures composed of inorganic nanoparticles appear in natural and synthetic systems, however the mechanisms of non-equilibrium self-organization that may be involved are still poorly understood. Herein, we performed a kinetic investigation of the precipitation of calcium phosp...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2020
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| Sorozat: | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
59 No. 7 |
| doi: | 10.1002/anie.201911213 |
| mtmt: | 31131403 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/18594 |
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| 100 | 1 | |a Bohner Bíborka | |
| 245 | 1 | 0 | |a Periodic Nucleation of Calcium Phosphate in a Stirred Biocatalytic Reaction |h [elektronikus dokumentum] / |c Bohner Bíborka |
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| 490 | 0 | |a ANGEWANDTE CHEMIE-INTERNATIONAL EDITION |v 59 No. 7 | |
| 520 | 3 | |a Highly ordered superstructures composed of inorganic nanoparticles appear in natural and synthetic systems, however the mechanisms of non-equilibrium self-organization that may be involved are still poorly understood. Herein, we performed a kinetic investigation of the precipitation of calcium phosphate using a process widely found in microorganisms: the hydrolysis of urea by enzyme urease. With high initial ratio of calcium ion to phosphate, periodic precipitation was obtained accompanied by pH oscillations in a well-stirred, closed reactor. We propose that an internal pH-regulated change in the concentration of phosphate ion is the driving force for periodicity. A simple model involving the biocatalytic reaction network coupled with burst nucleation of nanoparticles above a critical supersaturation reproduced key features of the experiments. These findings may provide insight to the self-organization of nanoparticles in biomineralization and improve design strategies of biomaterials for medical applications. | |
| 700 | 0 | 1 | |a Bánsági Tamás |e aut |
| 700 | 0 | 1 | |a Tóth Ágota |e aut |
| 700 | 0 | 1 | |a Horváth Dezső |e aut |
| 700 | 0 | 1 | |a Taylor Annette F. |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/18594/1/anie.201911213.pdf |z Dokumentum-elérés |