Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease
Long-term outcomes after percutaneous coronary intervention (PCI) with contemporary drug-eluting stents, as compared with coronary-artery bypass grafting (CABG), in patients with left main coronary artery disease are not clearly established.We randomly assigned 1905 patients with left main coronary...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
|
| Sorozat: | NEW ENGLAND JOURNAL OF MEDICINE
381 No. 19 |
| doi: | 10.1056/NEJMoa1909406 |
| mtmt: | 30828893 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/18015 |
| LEADER | 03369nab a2200373 i 4500 | ||
|---|---|---|---|
| 001 | publ18015 | ||
| 005 | 20200125114452.0 | ||
| 008 | 200125s2019 hu o 0|| zxx d | ||
| 022 | |a 0028-4793 | ||
| 024 | 7 | |a 10.1056/NEJMoa1909406 |2 doi | |
| 024 | 7 | |a 30828893 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Stone Gregg W. | |
| 245 | 1 | 0 | |a Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease |h [elektronikus dokumentum] / |c Stone Gregg W. |
| 260 | |c 2019 | ||
| 300 | |a 1820-1830 | ||
| 490 | 0 | |a NEW ENGLAND JOURNAL OF MEDICINE |v 381 No. 19 | |
| 520 | 3 | |a Long-term outcomes after percutaneous coronary intervention (PCI) with contemporary drug-eluting stents, as compared with coronary-artery bypass grafting (CABG), in patients with left main coronary artery disease are not clearly established.We randomly assigned 1905 patients with left main coronary artery disease of low or intermediate anatomical complexity (according to assessment at the participating centers) to undergo either PCI with fluoropolymer-based cobalt-chromium everolimus-eluting stents (PCI group, 948 patients) or CABG (CABG group, 957 patients). The primary outcome was a composite of death, stroke, or myocardial infarction.At 5 years, a primary outcome event had occurred in 22.0% of the patients in the PCI group and in 19.2% of the patients in the CABG group (difference, 2.8 percentage points; 95% confidence interval [CI], -0.9 to 6.5; P = 0.13). Death from any cause occurred more frequently in the PCI group than in the CABG group (in 13.0% vs. 9.9%; difference, 3.1 percentage points; 95% CI, 0.2 to 6.1). In the PCI and CABG groups, the incidences of definite cardiovascular death (5.0% and 4.5%, respectively; difference, 0.5 percentage points; 95% CI, -1.4 to 2.5) and myocardial infarction (10.6% and 9.1%; difference, 1.4 percentage points; 95% CI, -1.3 to 4.2) were not significantly different. All cerebrovascular events were less frequent after PCI than after CABG (3.3% vs. 5.2%; difference, -1.9 percentage points; 95% CI, -3.8 to 0), although the incidence of stroke was not significantly different between the two groups (2.9% and 3.7%; difference, -0.8 percentage points; 95% CI, -2.4 to 0.9). Ischemia-driven revascularization was more frequent after PCI than after CABG (16.9% vs. 10.0%; difference, 6.9 percentage points; 95% CI, 3.7 to 10.0).In patients with left main coronary artery disease of low or intermediate anatomical complexity, there was no significant difference between PCI and CABG with respect to the rate of the composite outcome of death, stroke, or myocardial infarction at 5 years. (Funded by Abbott Vascular; EXCEL ClinicalTrials.gov number, NCT01205776.). | |
| 700 | 0 | 1 | |a Kappetein Arie Pieter |e aut |
| 700 | 0 | 1 | |a Sabik Joseph F. |e aut |
| 700 | 0 | 1 | |a Pocock Stuart J. |e aut |
| 700 | 0 | 1 | |a Morice Marie-Claude |e aut |
| 700 | 0 | 1 | |a Puskas John |e aut |
| 700 | 0 | 1 | |a Kandzari David E. |e aut |
| 700 | 0 | 1 | |a Karmpaliotis Dimitri |e aut |
| 700 | 0 | 1 | |a Brown Morris W. |e aut |
| 700 | 0 | 1 | |a Lembo Nicholas J. |e aut |
| 700 | 0 | 1 | |a Merkely Béla Péter |e aut |
| 700 | 0 | 1 | |a Horkay Ferenc |e aut |
| 700 | 0 | 1 | |a Ungi Imre |e aut |
| 700 | 0 | 1 | |a Bogáts Gábor |e aut |
| 700 | 0 | 1 | |a EXCEL Trial Investigators |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/18015/1/2019_5_Years_Outcomes_NEJofMedicine.pdf |z Dokumentum-elérés |