Melanoma-Derived Exosomes Induce PD-1 Overexpression and Tumor Progression via Mesenchymal Stem Cell Oncogenic Reprogramming
Recently, it has been described that programmed cell death protein 1 (PD-1) overexpressing melanoma cells are highly aggressive. However, until now it has not been defined which factors lead to the generation of PD-1 overexpressing subpopulations. Here, we present that melanoma-derived exosomes, con...
Elmentve itt :
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| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
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| Sorozat: | FRONTIERS IN IMMUNOLOGY
10 |
| doi: | 10.3389/fimmu.2019.02459 |
| mtmt: | 30898978 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/17380 |
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| 490 | 0 | |a FRONTIERS IN IMMUNOLOGY |v 10 | |
| 520 | 3 | |a Recently, it has been described that programmed cell death protein 1 (PD-1) overexpressing melanoma cells are highly aggressive. However, until now it has not been defined which factors lead to the generation of PD-1 overexpressing subpopulations. Here, we present that melanoma-derived exosomes, conveying oncogenic molecular reprogramming, induce the formation of a melanoma-like, PD-1 overexpressing cell population (mMSCPD-1+) from naïve mesenchymal stem cells (MSCs). Exosomes and mMSCPD-1+ cells induce tumor progression and expression of oncogenic factors in vivo. Finally, we revealed a characteristic, tumorigenic signaling network combining the upregulated molecules (e.g., PD-1, MET, RAF1, BCL2, MTOR) and their upstream exosomal regulating proteins and miRNAs. Our study highlights the complexity of exosomal communication during tumor progression and contributes to the detailed understanding of metastatic processes. | |
| 700 | 0 | 1 | |a Harmati Mária |e aut |
| 700 | 0 | 1 | |a Dobra Gabriella |e aut |
| 700 | 0 | 1 | |a Németh István Balázs |e aut |
| 700 | 0 | 1 | |a Mihály Johanna |e aut |
| 700 | 0 | 1 | |a Zvara Ágnes |e aut |
| 700 | 0 | 2 | |a Hunyadi-Gulyás Éva Csilla |e aut |
| 700 | 0 | 2 | |a Katona Róbert László |e aut |
| 700 | 0 | 2 | |a Nagy István |e aut |
| 700 | 0 | 2 | |a Horváth Péter |e aut |
| 700 | 0 | 2 | |a Bálind Árpád |e aut |
| 700 | 0 | 2 | |a Szkalisity Ábel |e aut |
| 700 | 0 | 2 | |a Pankotai Tibor |e aut |
| 700 | 0 | 2 | |a Borsos Barbara Nikolett |e aut |
| 700 | 0 | 2 | |a Szegletes Zsolt |e aut |
| 700 | 0 | 2 | |a Buzás Krisztina |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/17380/1/30898978fimmu-10-02459.pdf |z Dokumentum-elérés |