Classical celiac disease is more frequent with a double dose of HLA-DQB1*02

Experimental data suggest that the HLA-DQ2 gene dose has a strong quantitative effect on clinical outcomes and severity of celiac disease (CD). We aimed to conduct a meta-analysis with systematic review to investigate the association between HLA-DQB1*02 gene doses and the characteristics of CD.We se...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Bajor Judit
Szakács Zsolt
Borbásné Farkas Kornélia
Hegyi Péter
Illés Anita
Varjú-Solymár Margit
Pétervári Erika
Balaskó Márta
Pár Gabriella
Sarlós Patrícia
Szűcs Ákos
Szemes Kata
Huszár Orsolya
Czimmer József
Varjú Péter
Vincze Áron
Dokumentumtípus: Cikk
Megjelent: 2019
Sorozat:PLOS ONE 14 No. 2
doi:10.1371/journal.pone.0212329

mtmt:30436456
Online Access:http://publicatio.bibl.u-szeged.hu/16785
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520 3 |a Experimental data suggest that the HLA-DQ2 gene dose has a strong quantitative effect on clinical outcomes and severity of celiac disease (CD). We aimed to conduct a meta-analysis with systematic review to investigate the association between HLA-DQB1*02 gene doses and the characteristics of CD.We searched seven medical databases for studies discussing HLA-DQB1 gene dose in CD and various disease characteristics, such as clinical presentation, histology, age at diagnosis, and comorbidities. Odds ratios (OR, for categorical variables) and weighted mean differences (for age) were calculated to compare patients with a double dose of HLA-DQB1*02 versus those with single and zero doses. Heterogeneity was tested with I2-statistics and explored by study subgroups (children and adults).Twenty-four publications were eligible for meta-analysis. Classical CD was more frequent with a double versus single dose of the HLA-DQB1*02 allele (OR = 1.758, 95%CI: 1.148-2.692, I2 = 0.0%). In pediatric studies, gene dose effect was more prominent (OR = 2.082, 95%CI: 1.189-3.646, I2 = 0.0% and OR = 3.139, 95%CI: 1.142-8.630, I2 = 0.0% for the comparisons of double versus single and double versus zero dose, respectively). Atrophic histology was more prevalent with a double versus zero dose (OR = 2.626, CI: 1.060-6.505, I2 = 21.3%). We observed no gene dose effect regarding diarrhea, age at diagnosis, the severity of villous atrophy, and the association with type 1 diabetes mellitus.A double dose of HLA-DQB1*02 gene seems to predispose patients to developing classical CD and villous atrophy. Risk stratification by HLA-DQB1*02 gene dose requires further clarification due to the limited available evidence. 
700 0 1 |a Szakács Zsolt  |e aut 
700 0 2 |a Borbásné Farkas Kornélia  |e aut 
700 0 2 |a Hegyi Péter  |e aut 
700 0 2 |a Illés Anita  |e aut 
700 0 2 |a Varjú-Solymár Margit  |e aut 
700 0 2 |a Pétervári Erika  |e aut 
700 0 2 |a Balaskó Márta  |e aut 
700 0 2 |a Pár Gabriella  |e aut 
700 0 2 |a Sarlós Patrícia  |e aut 
700 0 2 |a Szűcs Ákos  |e aut 
700 0 2 |a Szemes Kata  |e aut 
700 0 2 |a Huszár Orsolya  |e aut 
700 0 2 |a Czimmer József  |e aut 
700 0 2 |a Varjú Péter  |e aut 
700 0 2 |a Vincze Áron  |e aut 
856 4 0 |u http://publicatio.bibl.u-szeged.hu/16785/1/30436456_Bajor_journal.pone.0212329.pdf  |z Dokumentum-elérés