2-Iodo-4 '-Methoxychalcone Attenuates Methylglyoxal-Induced Neurotoxicity by Activation of GLP-1 Receptor and Enhancement of Neurotrophic Signal, Antioxidant Defense and Glyoxalase Pathway
Methylglyoxal (MG) acts as a reactive precursor of advanced glycation end products (AGEs). This compound is often connected with pathologies such as diabetes, neurodegenerative processes and diseases of aging. 2-iodo-4 '-methoxychalcone (CHA79), a synthetic halogen-containing chalcone derivativ...
Elmentve itt :
| Szerzők: | |
|---|---|
| Dokumentumtípus: | Cikk |
| Megjelent: |
2019
|
| Sorozat: | MOLECULES
24 No. 12 |
| doi: | 10.3390/molecules24122249 |
| mtmt: | 30759845 |
| Online Access: | http://publicatio.bibl.u-szeged.hu/16702 |
| LEADER | 02434nab a2200253 i 4500 | ||
|---|---|---|---|
| 001 | publ16702 | ||
| 005 | 20190909142521.0 | ||
| 008 | 190909s2019 hu o 0|| zxx d | ||
| 022 | |a 1420-3049 | ||
| 024 | 7 | |a 10.3390/molecules24122249 |2 doi | |
| 024 | 7 | |a 30759845 |2 mtmt | |
| 040 | |a SZTE Publicatio Repozitórium |b hun | ||
| 041 | |a zxx | ||
| 100 | 1 | |a Tseng Yu-Ting | |
| 245 | 1 | 0 | |a 2-Iodo-4 '-Methoxychalcone Attenuates Methylglyoxal-Induced Neurotoxicity by Activation of GLP-1 Receptor and Enhancement of Neurotrophic Signal, Antioxidant Defense and Glyoxalase Pathway |h [elektronikus dokumentum] / |c Tseng Yu-Ting |
| 260 | |c 2019 | ||
| 300 | |a Terjedelem: 14 p-Azonosító: 2249 | ||
| 490 | 0 | |a MOLECULES |v 24 No. 12 | |
| 520 | 3 | |a Methylglyoxal (MG) acts as a reactive precursor of advanced glycation end products (AGEs). This compound is often connected with pathologies such as diabetes, neurodegenerative processes and diseases of aging. 2-iodo-4 '-methoxychalcone (CHA79), a synthetic halogen-containing chalcone derivative, has been reported its anti-diabetic activity. This study aims to investigate the potential protective capability of CHA79 against MG-mediated neurotoxicity in SH-SY5Y cells. Results indicated CHA79 increased viability of cells and attenuated the rate of apoptosis in MG-exposed SH-SY5Y. CHA79 up-regulated expression of anti-apoptotic protein (Bcl-2) and down-regulated apoptotic proteins (Bax, cytochrome c, caspase-3, caspase-9). Moreover, CHA79 significantly up-regulated expression of neurotrophic factors, including glucagon-like peptide-1 receptor (GLP-1R), brain derived neurotrophic factor (BDNF), p75NTR, p-TrkB, p-Akt, p-GK-3 beta and p-CREB. CHA79 attenuated MG-induced ROS production and enhanced the antioxidant defense including nuclear factor erythroid 2-related factor 2 (Nrf2), HO-1, SOD and GSH. Furthermore, CHA79 attenuated MG-induced reduction of glyoxalase-1 (GLO-1), a vital enzyme on removing AGE precursors. In conclusion, CHA79 is the first novel synthetic chalcone possessing the GLP-1R and GLO-1 activating properties. CHA 79 also exhibits neuroprotective effects against MG toxicity by enhancing neurotrophic signal, antioxidant defense and anti-apoptosis pathway. | |
| 700 | 0 | 1 | |a Tsai Yi-Hong |e aut |
| 700 | 0 | 1 | |a Fülöp Ferenc |e aut |
| 700 | 0 | 1 | |a Chang Fang-Rong |e aut |
| 700 | 0 | 1 | |a Lo Yi-Ching |e aut |
| 856 | 4 | 0 | |u http://publicatio.bibl.u-szeged.hu/16702/1/yuting.pdf |z Dokumentum-elérés |