Traceless chirality transfer from a norbornene beta-amino acid to pyrimido[2,1-a]isoindole enantiomers

The synthesis of two enantiomeric pairs of pyrimidoisoindoles 9a, 9b and 10a, 10b is reported. During a domino ring-closure reaction, followed by cycloreversion, the chirality of diendo-(-)-(1R,2S,3MS)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide [(-)-1] was successfully transfered to heterocycles...

Teljes leírás

Elmentve itt :
Bibliográfiai részletek
Szerzők: Miklós Ferenc
Bozó Kristóf
Galla Zsolt
Haukka Matti
Fülöp Ferenc
Dokumentumtípus: Cikk
Megjelent: 2017
Sorozat:TETRAHEDRON-ASYMMETRY 28 No. 10
doi:10.1016/j.tetasy.2017.07.006

mtmt:3317911
Online Access:http://publicatio.bibl.u-szeged.hu/14936
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520 3 |a The synthesis of two enantiomeric pairs of pyrimidoisoindoles 9a, 9b and 10a, 10b is reported. During a domino ring-closure reaction, followed by cycloreversion, the chirality of diendo-(-)-(1R,2S,3MS)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide [(-)-1] was successfully transfered to heterocycles (+)-9a, (+)-10a, (-)-9b, (-)-10b and (-)-10c. (C) 2017 Elsevier Ltd. All rights reserved. 
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